Hypertension, diseases of aorta, arteries, veins and lymphatics Flashcards
how deadly is hypertension and why?
biggest killer in the world
because of the risk of cardiovascular disease and end-organ damage
what are the causes of hypertension?
no single cause
polifactorial and poligenic
what are the risks associated with hypertension?
heart failure CVA (stroke, MI) kidney failure vascular disease eye disease (retinopathy)
what are some of the risk factors for hypertension?
smoking diabetes age gender (male) obesity pregnancy alcoholism genetics/family history race hypercholesterolaemia environment salt intake stress
which family link is more likely to develop hypertension?
siblings and identical twins
which ethnicity is more likely to develop hypertension?
afrocaribbeans
what is defined as hypertension?
BP higher than 140/90
what types of hypertension are there, what is their prevalence?
primary hypertension (90%) secondary hypertension (10%)
what are the causes of primary hypertension?
often idiopathic
what are the causes of secondary hypertension?
kidney disease
pregnancy
endocrine disease
what is a potential cause for primary hypertension?
increased arteriolar resistance
what is the main target of treatment for hypertension?
the RAAS system
what is the approach to hypertension?
stepped approach
use low doses of multiple drugs
what are common drugs given for hypertension?
ACEi/ARB CCB thiazide diuretics methyldopa (pregnancy) nifedipine (pregnancy)
what treatments are given to pregnant women for hypertension/preeclampsia?
methyldopa
nifedipine
beta blocker
hydralazine
which subgroups should ACEi not be given to and why?
Older patients - because of kidney damage risk
Afrocaribbeans - because of angioedema risk
Pregnant women - because of teratogenicity
what treatment should be given first line to people over 55 and afrocaribbeans for hypertension?
Calcium channel blocker or thiazide diuretic
what are less commonly used drugs in hypertension?
doxazosin
methyldopa
hydralazine
what investigations should be done for hypertension?
Ambulatory BP meter
calculate risk (with online calculator)
ECG/kidney function tests (assess end-organ damage)
look for underlying treatable causes of HTN
what are the main non-pharmacological treatments for hypertension?
weight loss
smoking cessation
salt intake reduction
what are common risk factors for aortic aneurysms?
atherosclerosis hypertension smoking high cholesterol connective tissue diseases
what are the common types of aortic aneurysms?
saccular aneurysm
fusiform aneurysm
false (dissecting) aneurysm
what are some infectious/inflammatory diseases which cause aortic disease?
takayasu’s arteritis
syphilis
what are the imaging investigations carried out to diagnose aortic aneurysms?
Echocardiogram
CXR
MRI