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Pharmacology > Hypertension Classes > Flashcards

Hypertension Classes Flashcards

1
Q

metabolic pathway of lovastatin

A

P450 3A4 (CYP3A4)

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2
Q

class of furosemide

A

loop diuretics

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3
Q

metabolites in pitavastatin

A

no active metabolites

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4
Q

class of amlodipine

A

calcium channel blocker

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5
Q

class of eplerenone

A

potassium sparing diuretics

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6
Q

surface of atorvastatin

A

lipophilic

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7
Q

class of lovastatin

A

statin

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8
Q

metabolic pathway of rosuvastatin

A

CYP2C9

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9
Q

metabolites in pravastatin

A

no active metabolites, the major metabolites are produced by chemical degradation in the stomach rather than by cytochrome P450-dependent metabolism in the liver.

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10
Q

class of torsemide

A

loop diuretics

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11
Q

class of losartan

A

angiotensin II receptor blocker

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12
Q

class of prazosin

A

alpha adrenergic antagonist

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13
Q

metabolic pathway of pravastatin

A

renal metabolism

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14
Q

metabolite in simvastatin

A

active metabolite

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15
Q

class of metoprolol

A

beta blocker

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16
Q

class of valsartan

A

angiotensin II receptor blocker

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17
Q

surface of fluvastatin

A

lipophilic

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18
Q

class of hydrochlorothiazide

A

thiazide diuretic

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19
Q

class of penbutolol

A

beta blocker

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20
Q

class of sotalol

A

beta blocker

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21
Q

metabolite in fluvastatin

A

no active metabolites

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22
Q

metabolic pathway of simvastatin

A

P450 3A4 (CYP3A4)

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23
Q

metabolic pathway of fluvastatin

A

CYP2C9

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24
Q

class of vadlolol

A

beta blocker

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25
Q

metabolism of losartan

A

cytochrome P450 (CYP) 3A4, 2C9 and 2C10 isoenzymes

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26
Q

surface of rosuvastatin

A

hydrophilic

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27
Q

class of simvastatin

A

statin

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28
Q

class of moexipril

A

ACE inhibitor

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29
Q

class of nisoldipine

A

calcium channel blocker

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30
Q

class of esmilol

A

beta blocker

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31
Q

class of felodipine

A

calcium channel blocker

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32
Q

class of enalapril

A

ACE inhibitor

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33
Q

surface of lovastatin

A

lipophilic

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34
Q

surface of pravastatin

A

hydrophilic

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35
Q

metabolites in atorvastatin

A

active metabolite

36
Q

class of atenolol

A

beta blocker

37
Q

class of quinapril

A

ACE inhibitor

38
Q

class of perindopril

A

ACE inhibitor

39
Q

class of olmesartan

A

angiotensin II receptor blocker

40
Q

class of acebutolol

A

beta blocker

41
Q

metabolic pathway of pitavastatin

A

little metabolism by CTP3A4

42
Q

class of captopril

A

ACE inhibitor

43
Q

class of candesartan

A

angiotensin II receptor blocker

44
Q

common SE of amlodipine

A

lower extremity swelling

45
Q

class of chlorthalidone

A

thiazide diuretic

46
Q

class of lisinopril

A

ACE inhibitor

47
Q

metabolic pathway of atorvastatin

A

P450 3A4 (CYP3A4)

48
Q

class of rosuvastatin

A

stain

49
Q

class of fluvastatin

A

statin

50
Q

class of pitavastatin

A

statin

51
Q

class of irbesartan

A

angiotensin II receptor blocker

52
Q

class of spironolactone

A

potassium sparing diuretics

53
Q

class of carvedilol

A

beta blocker

54
Q

class of atorvastatin

A

statin

55
Q

class of terazosin

A

alpha adrenergic antagonist

56
Q

class of azilsartan

A

angiotensin II receptor blocker

57
Q

class of nebivolol

A

beta blocker

58
Q

class of propanolol

A

beta blocker

59
Q

metabolites in rosuvastatin

A

minor active metabolite

60
Q

class of verapamil

A

calcium channel blocker

61
Q

class of nicardipine

A

calcium channel blocker

62
Q

class of triamterene

A

potassium sparing diuretics

63
Q

class of ramipril

A

ACE inhibitor

64
Q

class of bisoprolol

A

beta blocker

65
Q

class of telmisartan

A

angiotensin II receptor blocker

66
Q

class of fosinopril

A

ACE inhibitor

67
Q

class of labetolol

A

beta blocker

68
Q

class of benazepril

A

ACE inhibitor

69
Q

class of doxazosin

A

alpha adrenergic antagonist

70
Q

class of pravastatin

A

statin

71
Q

class of trandolapril

A

ACE inhibitor

72
Q

class of nifedipine

A

calcium channel blocker

73
Q

class of chlorothiazide

A

thiazide diuretic

74
Q

class of amiloride

A

potassium sparing diuretics

75
Q

surface of pitavastatin

A

lipophilic

76
Q

class of diltiazem

A

calcium channel blocker

77
Q

surface of simvastatin

A

lipophilic

78
Q

metabolites in lovastatin

A

active metabolite

79
Q

class of eprosartan

A

angiotensin II receptor blocker

80
Q

class of bumetanide

A

loop diuretics

81
Q

class of metolazone

A

thiazide diuretic

82
Q

where does drug metabolism occur??

A

liver, intestinal wall, lungs, kidney, plasma

83
Q

what is the main function of the liver with respect to drug metabolism?

A

enzymatically convert lipid soluble compounds to more water soluble compounds

84
Q

mechanism of action of drug interactions with CYP metabolized drugs?

A

CYP related drugs inhibit or induce metabolism, affecting the metabolism of the other drugs (subtherapeutic or increased concentration of drug)

85
Q

how could grapefruit be toxic for certain drugs?

A

inhibits CYP3A4, acts locally on small intestine and inhibits enterocyte CYP3A4, causing higher systemic levels of CYP3A4 active drugs

Pharmacology (5 decks)

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