Analgesics Flashcards
Where are COX1 receptors expressed
normal tissues, GI tract, kidneys, platelets
Where are COX2 receptors expressed
not normally present, but are induced to inflammatory stimuli
What does the stimulation of COX2 result in?
prostaglandins that activate and sensitize nociceptors
Indications for non-opioid analgesics? like COX1 and COX2 inhibitors?
effective for somatic pain, muscle/joint, bone/dental, inflammatory, postop
Benefits of using celecoxib?
does not inhibit platelet aggregation, less likely to cause GI distress
What is the downfall of acetaminophen/
has negligent anti-inflammatory effects, acute or chronic OD may cause liver or kidney toxicity
Class of acetaminophen
paraminophenol
Indication for acetaminophen
HA, toothache, muscle ache, menstrual cramp, arthritis, cold and flu fever reduction (esp in children)
What drugs are in the salicylate class?
aspirin, diflunisal (dolobid), CMT (choline magnesium trisalicylate), trolamine salicylate (lotion/cream)
Benefit of diflunisal vs aspirin?
less GI irritation and less antiplatelet effects than aspirin
What drugs are considered propionic acid derivative class? (5)
ibuprofen (advil, motrin), naproxen (aleve), ketoprofen, flurbiprofen, oxaprozin
Benefits of ibuprofen vs other NSAIDS
less GI effects
What are the special indications for naproxen?
RA, OA, ankylosing spondylitis, juvenile arthritis, gout, dysmenorrhea (primary)
unique SE of naproxen?
pseudoporphyria (photosensitivity)(mimics the buildup of porphyrin)
unique indications of ketoprofen?
OA, RA, primary dysmenorrhea
