Hypertension Flashcards
with every increase of 20/10 mmHg in BP, how much does CV mortality risk increase?
it doubles
why must you take many readings and average them when using electric BP monitors?
they are less accurate than manual ones
Automated BP devices might not measure BP properly if there’s a pulse irregularity. True/ false?
True - so palpate pulse first to ensure it’s regular
how should BP be checked in people with symptoms of postural hypotension?
- measure BP supine or seated
- measure BP again after standing for 1 minute
- if systolic BP falls by 20mmHg or more: review medication, measure subsequent BPs with person standing, consider referral if symptoms persist
at what level of BP should ABPM be offered
clinic BP of 140/90mmHg (to confirm the diagnosis)
what should be done when considering diagnosis of hypertension?
- measure BP in both arms
- if difference is more than 20mmHg, repeat measurements.
- if it remains more than 20 difference - take 2 more readings in the arm with the higher reading
- if BP in clinic is over 140/90mmHg - take a second measurement. If this is substantially different - take a third. Record the lower of the last two measurements as the clinic BP.
what can be offered if person cannot tolerate ABPM?
HBPM
If severe hypertension - start treatment before getting ABPM/ HBPM results
how should ABPM be used?
take at least 2 measurements per hour during the person’s waking hours to confirm hypertension
how should HBPM be used?
- should be 2 consecutive seated measurements, 1 minute apart
- BP recorded twice daily (ideally morning and evening)
- BP recording continues for at least 4 days (ideally 7)
- discard the measurements of the first day and use the average of all the remaining measurements to confirm hypertension
what should be done if hypertension is not diagnosed, but there is evidence of target organ damage e.g. LV hypertrophy, albuminuria, proteinuria?
carry out investigations for alternative causes for the target organ damage
what is hypertension is not diagnosed after ABPM/ HBPM?
measure the person’s clinic BP every 5 years, maybe more often if BP is close to 140/90mmHg
define stage I hypertension?
clinic BP 140/90mmHg
AND
ABPM/ HBPM is 135/85mmHg
define stage II hypertension?
clinic BP 160/100mmHg
AND ABPM/ HBPM is 150/95mmHg
define severe hypertension?
clinic BP is 180mmHg
OR
clinic diastolic is 110mmHg
what tests should be offered to all with hypertension?
- test urine for protein
- test blood to measure glucose, electrolytes, creatinine, estimated glomerular filtration rate and cholesterol
- examine fundi for hypertensive retinopathy
- 12 lead ECG
what tool can be used to calculate risk?
assign score
what should be included in the assessment of the patient?
- medical history
- FH premature CV disease
- smoking
- repeated BPs (or ABPM or HBPM)
- examine fundi?
grade I hypertensive retinopathy?
slight / modest narrowing of the retinal arterioles, with an arteriovenous ratio > / = 1:2
grade II hypertensive retinopathy?
modest to severe narrowing of retinal arterioles (focal / generalised) with an arteriovenous ratio<1:2 OR arteriovenous nicking
grade III hypertensive retinopathy?
bilateral soft exudates or flame-shaped haemorrhages
grade IV hypertensive retinopathy?
bilateral optic nerve oedema
should ACE inhibitors ever be combined with ARBs?
No
what is first line anti-hypertension drug in those under 55 (white)?
ACE inhibitor
ARBs if can’t tolerate cough
what is the first line anti-hypertension drug in those over 55/ black?
calcium channel blockers
(if this is not suitable e.g. oedema/ intolerance/ heart failure/ risk of heart failure) –> offer a thiazide-like diuretic
what’s the target BP in those under 80
140/90mmHg
135/85 at home
what’s the target BP in those over 80?
150/90mmHg
145/85 at home
what does a discrepancy of more than 20/10mmHg between clinic and home BPM suggest?
white coat effect
by what percentage does a 5mmHg drop in DIASTOLIC BP have on stroke risk and CHD risk?
stroke risk decreases by 40%
CHD risk decreases by 25%
how can polycystic kidney disease (genetic condition) contribute to hypertension?
means you cannot excrete Na - so blood volume increases too
what tool can be used to detect obstructive sleep apnoea?
the Epworth Sleepiness scale
how can Conn’s syndrome (primary hyperaldosteronism) cause hypertension?
RAAS system excessive due to increased aldosterone
severe hypertension
severe hypokalaemia too
how can phaeochromocytoma cause hypertension?
releases too much adrenaline and noradrenaline
how can renal artery stenosis cause hypertension?
restricts blood flow to the kidney (proven now that there’s no benefit in stenting these people)
how can fibromusclar dysplasia cause hypertension?
It’s a non-atherosclerotic, non-inflammatory disease of the blood vessels that causes abnormal growth within the artery wall (any artery in the body). Most common are the renal and carotid arteries.
what lifestyle advice to lower CVS risk can be given?
- diet (reduce salt and caffeine intake), weight reduction and exercise
- alcohol
- smoking
what education can you provide to the patient to encourage adherence to drugs?
- information about benefits of drugs and side effects
- details of patient organisations
- an annual review of care
how much is BP reduced by for every 1kg of weight lost?
1mmHg
what is the minimum amount of physical activity a day for reduced mortality and extended life expectancy?
15 minutes a day (14% reduced mortality)
an extra 15min on top of this gives an extra 4% reduced mortality
how much does a “no salt added” diet lower BP by?
2-4mmHg
how much does the DASH (Dietary Approaches to Stop Hypertension) diet reduce BP by?
11.4 / 5.5 mmHg
how much does aerobic exercise reduce BP by?
3/8/2.6mmHg
if people are high risk for CVS disease, but are normotensive - would they still benefit from BP and cholesterol lowering?
Yes
aside from hypertension, what can B-blockers also be used for?
angina
aside from hypertension, what can ACE-inhibitors/ ARBs also be used for?
diabetic nephropathy
aside from hypertension, what can ACE-inhibitors / B-blockers also be used for?
diabetic nephropathy
aside from hypertension, what can a-blockers also be used for?
benign prostatic hyperplasia
aside from hypertension, what can thiazides also be used for?
use in the elderly
why are ACE-inhibitors not given to fertile women? What is given instead?
they are teratogenic
consider an a/ B-blocker instead
adding drug combinations is more effective than increasing the doses. True/ false?
True
reduced BP more and reduces side effects
reasons for resistant hypertension?
non-concordance white coat effect pseudo-hypertension lifestyle factors drug interactions secondary hypertension true resistance
what drug class is spironolactone and how does it work?
it’s a potassium sparing diuretic
it blocks aldosterone receptors
very effective at reducing BP
how should spironolactone be used?
- start low, go slow
- use with caution in diabetics and low GFR (risk of hyperkalaemia)
- tolerate a 25% increase in K and creatinine
what is renal de-nervation?
the nerves are ablated (reducing sympathetic and efferent connections) so BP reduced in those with resistant hypertension
carotid baroreceptor stimulation
baroreceptors stimulated to increase parasympathetic activity (and decrease sympathetic) and so decrease BP
ROX AV fistula device?
new method of BP reduction