Hypersensitivity reactions Flashcards
type I
A
type II
C
type III
I
type IV
D
anaphylactic (immediate)
A - type I
rapid (15-30 min) to react
A - type I
bronchial asthma (allergy) bee sting, hay fever
A - type I
IgE, mast cell, basophils
A - type I
cytotoxic
C - type II
mins to hours to react
C - type II
good pasteur's (lung + kidney) erythroblastosis fetalis = coombs anemia blood transfusions myasthenia gravis grave's disease
C - type II
IgG involved
targets cell for phagocytosis
2 things = antigen+antibody
C - type II
immune complex mediated
I - type III
3-10 hours to react
I - type III
glomerulonephritis, lupus, RA
arthus rxn - local necrosis
serum sickness - systemic
I - type III
IgG and complement
3 things = antigen+antibody+complement
I - type III
delayed hyper-sensitivity (cell mediated)
D - type IV
48 hours to react
D - type IV
TB, contact dermatitis (poison ivy, poison oak)
transplant rejection via MHC
D - type IV
t-cell
lymphocytes
D - type IV