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IMSE 311 > Hypersensitivity > Flashcards

Hypersensitivity Flashcards

1
Q

Normal but exaggerated or uncontrolled immune response to an antigen that can produce inflammation, cell destruction, or tissue injury

A

Hypersensitivity

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2
Q

An exaggerated response to harmless antigen that results an injury to the tissue, disease, or even death

A

Hypersensitivity

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3
Q

Two British immunologists that devised a classification system for such reactions based on four categories

A

P.G.H. Gell and R.R.A. Coombs

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4
Q

Immunologic reaction dependent on the host response to a subsequent exposure of antigen

A

Immunization/ Sensitization

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5
Q

Refers to immediate hypersensitivity mediated by IgE

A

Allergy/ Atopy

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6
Q

Reaction: Anaphylactic/ Immediate
Antibody: IgE
Complement: None
Cytokines: Yes
Cells Involved: Mast cells, Basophil

A

Type I

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7
Q

Reaction: Cytotoxic/ Ab cytotoxic mediated
Antibody: IgG
Complement: Yes
Cytokines: None
Cells Involved: Effector cell: Macrophage, Neutrophil

A

Type II

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8
Q

Reaction: Immune Complex/ Complex mediated
Antibody: Ag-Ab Complex (IgG, IgM)
Complement: Yes
Cytokines: Yes
Cells Involved: Macrophage

A

Type III

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9
Q

Reaction: T-cell Dependent/ Delayed/ Hypersensitivity
Antibody: None
Complement: None
Cytokines: T cell cytokine
Cells Involved: Antigen-Specific T cell

A

Type IV

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10
Q

Its immune mechanism is to release mediators from mast cells and basophils

Examples:
Anaphylaxis, Hay Fever, Food allergies, Asthma

A

Type I

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11
Q

Immune mechanism is cytolysis due to antibody and complement (tissue specific)

Examples:
Transfusion Reactions, Autoimmune Hemolytic Anemia, HDN, Grave’s Disease, Goodpasture’s syndrome, Antibacterial Antibodies, Viral Disease Prevention, HTR, ITP, HTR

A

Type II

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11
Q

Immune mechanism is deposits of antigen-antibody complexes (systemic)

Examples:
Serum sickness Arthus Reaction, Lupus Erythematosus, Glomerulonephritis, Vasculitis (Polyarteritis nodosa, Rheumatoid Arthritis)

A

Type III

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11
Q

Its immune mechanism is the release of cytokines

Examples:
Contact dermatitis, Tuberculin Test, Hypersensitivity Pneumonitis

A

Type IV

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11
Q

Immune complex deposition

A

Type III

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11
Q

Antibody Mediated and Immediate Reaction

A

Type I

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12
Q
  • Cell bound antibody reacts with antigen to release physiologically active substances
  • Has the short time lag, usually seconds - mins., between exposure to antigen and the onset of clinical symptoms
  • Key reactant or immediate sensitivity reaction is IgE
A

Type I Hypersensitivity

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12
Q

Antibody Dependent; Complement or Cell Mediated

A

Type II

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12
Q

Inflammation, Cellular infiltration

A

Type IV

13
Q

Antigens that trigger formation of IgE are called ____?

A

Atopic antigens or allergens

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IMSE 311 (4 decks)

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