Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathophysiology > Hypersensitivity > Flashcards

Hypersensitivity Flashcards

1
Q

what is hypersensitivity?

A

excessive/inappropriate activation of immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

which type of reaction involves the classic allergic rxns, is IgE mediated and has a fast onset?

A

Type 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the manifestations of Type 1?

A

swelling, redness, anaphylactic reactions, normal reaction to allergens, inflammation in nasal membranes and can lead to mucosal edema, bronchial constriction and epithelial damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What type of reaction is cytotoxic and antibody mediated?

A

type 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are examples of a Type 2 reaction?

A

blood transfusion, drug reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which type of reaction involves antigen-antibody (immune) complexes?

A

Type 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the manifestations of a type 3 reaction?

A

inflammation, chills, fever, rash, arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which type of reaction is cell-mediated and is delayed?

A

Type 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are examples of a Type 3 reaction?

A

glomerulonephritis, SLE and rheumatoid arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the two types of Types 4 reactions?

A

direct (CD8 cells) and delayed type (CD4 cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are manifestations of a type 4 reaction?

A

rash, fever, multiorgan involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what are examples of Type 4 reaction?

A

allergic contact dermatitis, hypersensitivity dermatitis, hypersensitivity pneumonitis, transplantation rejection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are common unifying features of hypersensitivity disorders?

A

anaphylaxis, inflammation, fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which cells are involved in a Type 1 reaction?

A

Helper T cells, mast cells or basophils, lipid mediators, cytokines, eosinophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the role of the Helper T cells in a type 1 reaction?

A

T1H cells stimulate the differentiation of B cells; T2H cells direct B lymphocytes to switch class and produce IgE antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the role of mast cells/basophils in a type 1 reaction?

A

they degranulate, releasing histamine, and cause vasodilation which leads to anaphylaxis

17
Q

what is a primary reaction in Type 1?

A

within 5-30 minutes of exposure; subsides within 60 minutes; mediated by acute mast cell degranulation

18
Q

what is a secondary reaction in Type 1?

A

within 2-8 hours; can last for several days; results from the release of cytokines and lipid mediators; role of eosinophils

19
Q

what is anaphylaxis?

A

a systemic response to the inflammatory mediators released in Type 1 reaction

Pathophysiology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions