Hyperlipidemia Drugs

Question 1

Target terapi hiperlipidemia adalah:
total kolesterol < ___
TGL < ___
LDL < ___
HDL >___

Answer 1

total kolesterol < 200
TGL < 150
LDL < 100
HDL >60

Question 2

1st line hiperlipidemia untuk TG<500

Answer 2

Statin

Question 3

1st line hiperlipidemia untuk TG>500

Answer 3

fibrat

Question 4

2nd and 3rd line hiperlipidemia:

Answer 4

Statin (leave out if patient is intolerant)
2nd line: Inhibitor absorbsi kolesterol
2nd line (LDL>140) : inhibitor PCSK9

when 2nd line fails
3rd line: Resin asam empedu

Question 5

Statin low intensity yg dapat menjadi medium intensity (beserta dosis) hint: SiPLov, dosis x2

Answer 5

Simvastatin (10//20-40)
pravastatin (20//40-80)
Lovastatin (20//40-80)

Question 6

Statin medium intensity yang dapat menjadi high intensity (beserta dosis) hint: RosA, dosis x2

Answer 6

Rosuvastatin (10//20-40)
Atorvastatin (20//40-80)

Question 7

Contoh Fibrat

Answer 7

Fenofibrat
Gemfibrozil
Klofibrat

Question 8

Contoh 2nd line obat HL untuk pasien LDL<140 dan MoA

Answer 8

Inhibitor Absorbsi Kolesterol : Ezetimibe
MoA: mencegah penyerapan kolesterol di lambung

Question 9

contoh 2nd line obat HL untuk pasien LDL>140 (hint: ABEcumab)

Answer 9

Inhibitor PCSK9:
Alitocumab
Bococicumab
Evolocumab

Question 10

Contoh 3rd line obat HL + MoA (hint: Coles)

Answer 10

Resin asam empedu: Colestipol
Coleselvam
Colestiramin

MOA: menyerap asam empedu di usus -> penyerapan kolesterol tidak berjalan

Question 11

obat HL untuk pasien Hamil

Answer 11

Resin asam empedu (Coles)
or
PUFA omega 3

KI statin