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Pharmacotherapy > Anti Inflammatory Drugs > Flashcards

Anti Inflammatory Drugs Flashcards

Drug name, Indication, Class, Side Effect

1
Q

Aspirin, Ketoprofen, diclofenac, meclofenamate, Ibuprofen 5 indications

A

Pain, Fever, Arthritis, Dysmenorrhea (pain during period), patent ductus arteriosis (heart defect)

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2
Q

Aspirin, Ketoprofen, Diclofenac, meclofenamate Ibuprofen 3 short term use side effect, 1 aspirin specific

A

GI tract disturbance, skin disorder, blood disorder

Aspirin : aspirin-induced asthma

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3
Q

Aspirin, Ketoprofen, Diclofenac, meclofenamate, Ibuprofen long term use side effect

A

Nephrotoxicity (due to reduced blood flow)

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4
Q

Aspirin, acetaminophen, diclofenac, meclofenamate is anti-inflammatory. T/F?

A

F. Acetaminophen is not anti-inflammatory.

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5
Q

Aspirin, ketoprofen, diclofenac, meclofenamate, ibuprofen is NSAID with short half life (1-5H). T/F?

A

T

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6
Q

Meloxicam, Naproxen, Piroxicam is non-selective cox inhibitor (NSAID). T/F?

A

T

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7
Q

Aspirin, acetaminophen, diclofenac is selective cox-2 inhibitor, T/F?

A

F, non-selective.

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8
Q

NSAID with least toxicity

A

Naproxen

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9
Q

ADE of NSAID

A

A : well absorbed orally
D : highly bound to plasma protein, accumulate in sites of inflam with lower pH
E : kidneys (glomerular / tubular secretion)

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10
Q

NSAID with least GI irritation

A

Celecoxib, diflunisal

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11
Q

NSAID with high chance of upper GI disturbance

A

Aspirin, indomethacin

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12
Q

Very potent NSAID, used after less toxic agents are proven ineffective

A

Indomethacin

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13
Q

3 indications for selective COX-2 inhibitor

A

acute pain, osteoarthritis, rheumatoid arthritis

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14
Q

3 advantages of selective cox-2 inhibitor vs non-selective

A

less kidney damage
less GI tract disturbance
no inhibition of platelet aggregation

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15
Q

3 disadvantages of selective cox-2 inhibitor

A

cardiovascular and liver disorder, potentially increase stroke

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16
Q

drug that has antipyretic and analgesic properties but not anti-inflammatory

A

acetaminophen

17
Q

Rofecoxib, celecoxib, valdecoxib have less kidney damage compared to aspirin. T/F?

A

T

18
Q

Celecoxib should be given to a patient with dysmenorrhea who has a heart condition. T/F?

A

F. avoid selective NSAIDS for patients with heart and liver condition

19
Q

Celecoxib should be given to a patient with osteoarthritis who has a compromised kidney function. T/F?

A

T

20
Q

Aspirin, ketoprofen, fenoprofen, ibuprofen can inhibit blood clotting. T/F?

A

T. They are non-selective COX inhibitors, and can inhibit blood clotting.

21
Q

Fluticasone, and prednisone are short-medium acting glucocorticoids. T/F?

A

T

22
Q

2 long acting glucocorticoid

A

dexamethasone, betamethasone

23
Q

Which SAID can be used as imunosupressant?

A

dexamethasone, betamethasone (long acting NAIDS)

24
Q

prednisolone causes constipation. T/F?

A

F.

25
Q

SAIDS can be used to treat conditions caused by allergies. T/F?

A

T

26
Q

Cortisone, prednisolone, dexamethasone, ibuprofen, ketoprofen, diflunisal, valdecoxib, rofecoxib. Group these into non selective, selevtice NSAIDS and also SAIDS

A

non-selective NSAID : profens + diflunisal
selective NSAID : coxibs
SAIDS: sone, solone

27
Q

Which anti-inflammatory group can be used to treat psoriasis and eczema? name 3 examples

A

SAIDS (glucocorticoids). Dexamethasone, prednisolone, hydrocortisone

28
Q

Which glucocorticoids are available for topical use?

A

betamethasone, dexamethasone (long acting)
triamcinolone (medium acting)
hydrocortisone (short-medium acting)

29
Q

which glucocorticosteroids are not injectable?

A

cortisone, prednisone, fluprednisolone, fludrocortisone

30
Q

Which glucocorticoids are available orally?

A

All are.

31
Q

Can glucocorticoid use be stopped abruptly? Why?

A

No, can cause acute adrenal insufficiency

32
Q

NSAIDS used as first line treatment of primary dysmenorrhea (no underlying condition that cause dysmenorrhea)

A

mefenamic acid
ibuprofen
Celecoxib
naproxen

source: american family physician 2014

33
Q

The first line treatment of acute gout attack (asam urat >6mg/dL) that does not require a prescription is?

A

diclofenac (sodium diklofenak), an NSAID

34
Q

3 non-selective NSAIDS that has higher affinity for cox-2 receptors

A

meloxicam
diclofenac (sodium diklofenak)
etodolac

35
Q

asam mefenamat merupakan obat wajib apotek. T/F?

A

T

Pharmacotherapy (6 decks)

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