Anti Inflammatory Drugs Flashcards
Drug name, Indication, Class, Side Effect
Aspirin, Ketoprofen, diclofenac, meclofenamate, Ibuprofen 5 indications
Pain, Fever, Arthritis, Dysmenorrhea (pain during period), patent ductus arteriosis (heart defect)
Aspirin, Ketoprofen, Diclofenac, meclofenamate Ibuprofen 3 short term use side effect, 1 aspirin specific
GI tract disturbance, skin disorder, blood disorder
Aspirin : aspirin-induced asthma
Aspirin, Ketoprofen, Diclofenac, meclofenamate, Ibuprofen long term use side effect
Nephrotoxicity (due to reduced blood flow)
Aspirin, acetaminophen, diclofenac, meclofenamate is anti-inflammatory. T/F?
F. Acetaminophen is not anti-inflammatory.
Aspirin, ketoprofen, diclofenac, meclofenamate, ibuprofen is NSAID with short half life (1-5H). T/F?
T
Meloxicam, Naproxen, Piroxicam is non-selective cox inhibitor (NSAID). T/F?
T
Aspirin, acetaminophen, diclofenac is selective cox-2 inhibitor, T/F?
F, non-selective.
NSAID with least toxicity
Naproxen
ADE of NSAID
A : well absorbed orally
D : highly bound to plasma protein, accumulate in sites of inflam with lower pH
E : kidneys (glomerular / tubular secretion)
NSAID with least GI irritation
Celecoxib, diflunisal
NSAID with high chance of upper GI disturbance
Aspirin, indomethacin
Very potent NSAID, used after less toxic agents are proven ineffective
Indomethacin
3 indications for selective COX-2 inhibitor
acute pain, osteoarthritis, rheumatoid arthritis
3 advantages of selective cox-2 inhibitor vs non-selective
less kidney damage
less GI tract disturbance
no inhibition of platelet aggregation
3 disadvantages of selective cox-2 inhibitor
cardiovascular and liver disorder, potentially increase stroke
drug that has antipyretic and analgesic properties but not anti-inflammatory
acetaminophen
Rofecoxib, celecoxib, valdecoxib have less kidney damage compared to aspirin. T/F?
T
Celecoxib should be given to a patient with dysmenorrhea who has a heart condition. T/F?
F. avoid selective NSAIDS for patients with heart and liver condition
Celecoxib should be given to a patient with osteoarthritis who has a compromised kidney function. T/F?
T
Aspirin, ketoprofen, fenoprofen, ibuprofen can inhibit blood clotting. T/F?
T. They are non-selective COX inhibitors, and can inhibit blood clotting.
Fluticasone, and prednisone are short-medium acting glucocorticoids. T/F?
T
2 long acting glucocorticoid
dexamethasone, betamethasone
Which SAID can be used as imunosupressant?
dexamethasone, betamethasone (long acting NAIDS)
prednisolone causes constipation. T/F?
F.
SAIDS can be used to treat conditions caused by allergies. T/F?
T
Cortisone, prednisolone, dexamethasone, ibuprofen, ketoprofen, diflunisal, valdecoxib, rofecoxib. Group these into non selective, selevtice NSAIDS and also SAIDS
non-selective NSAID : profens + diflunisal
selective NSAID : coxibs
SAIDS: sone, solone
Which anti-inflammatory group can be used to treat psoriasis and eczema? name 3 examples
SAIDS (glucocorticoids). Dexamethasone, prednisolone, hydrocortisone
Which glucocorticoids are available for topical use?
betamethasone, dexamethasone (long acting)
triamcinolone (medium acting)
hydrocortisone (short-medium acting)
which glucocorticosteroids are not injectable?
cortisone, prednisone, fluprednisolone, fludrocortisone
Which glucocorticoids are available orally?
All are.
Can glucocorticoid use be stopped abruptly? Why?
No, can cause acute adrenal insufficiency
NSAIDS used as first line treatment of primary dysmenorrhea (no underlying condition that cause dysmenorrhea)
mefenamic acid
ibuprofen
Celecoxib
naproxen
source: american family physician 2014
The first line treatment of acute gout attack (asam urat >6mg/dL) that does not require a prescription is?
diclofenac (sodium diklofenak), an NSAID
3 non-selective NSAIDS that has higher affinity for cox-2 receptors
meloxicam
diclofenac (sodium diklofenak)
etodolac
asam mefenamat merupakan obat wajib apotek. T/F?
T
