Hyperlipidemia Flashcards
What are the most potent statins?
Rosuvastatin (Crestor) & Atoravastatin (Lipitor)
Dosing of statins is dependent on ___________.
degree of LDL reduction required. Take: (Pts LDL-goal)/Pt’s LDL.
What is the most efficacious statin?
Rosuvastatin (Crestor)
What are the NCEP ATP III Guidelines for risk factors for statins?
Major risk factors (exclusive of LDL cholestrol) that modify LDL goals:
cigarette smoking, HTN, low HDL cholestrol, FHx of premature CHD (men < 55, women < 65), and Age (men > 45, women > 55)
What is the first step in controlling HTN?
Lifestyle modifications. ALWAYS!
What medications can increase HDL?
Fibrates & Niacin, (BAS to a small degree)
What are the adverse effects of statins?
muscle pains and rhabdo
What are the adverse effects of fibrates?
GI, cholelithiasis, elevated liver enzymes. If used with statins there is an increased risk of myopathy/rhabdo
What are the adverse effects of gemfibrozil?
GI, cholelithiasis, elevated liver enzymes. If used with statins there is an increased risk of myopathy/rhabdo. Potentially higher risk than fibrates.
What do we need to do before starting meds for hyperlipidemia?
baseline LFT and CK-MB and monitor this while patient is on the drug.
Which medication increases LDL?
fish oil
Define Hyperlipidemia.
abnormal lipid levels
What guidelines do we use for lipids?
ATP III and Framingham
What are secondary goals for hyperlipidemia tx?
HDL and TG
What is the mechanism of action for statins?
lower production of cholestrol and interfere with hepatic production
