Hyperlipidemia Flashcards
MOA of HMG-CoA reductase inhibitors
- blocks cholesterol synthesis in liver
- increase in synthesis of cholesterol receptors
- increased clearance of LDL
- lower total & LDL
MOA of HMG-CoA
catalyses the conversion of HMG-CoA to mevalonic acid
Liver AEs of HMG-CoA reductase
increase in liver enzymes
** liver function test at baseline, 3, 6, 12 months, then yearly
what do HMG-CoAs end with
Statin
List bile binding resins
Cholestyramine
Colestipol
Colesevelam
MOA of bile binding resins
bind to negatively charged bile in small intestine –> resins not absorbed or metabolized –> body compensats by converting cholesterol into bile acids –> lowered cholesterol level
what do statins do to LDL, HDL, triglycerides
↓ LDL-cholesterol by 25-55%
↑ HDL-cholesterol by 5%
↓ triglycerides by 10-35%
what do bile binding resins do to LDL, HDL, triglycerides
↓ LDL-cholesterol by 15-30%
↑ HDL-cholesterol by 3-5%
Triglycerides: no effect or ↑
list fibrates
Gemfibrozil
fenofibrate
what do fibrates do to LDL, HDL, triglycerides
↓ LDL-cholesterol by 5-20%
↑ HDL-cholesterol by 10-35%
↓ triglycerides by 20-50%
niacin is also known as
nicotinic acid
MOA of niacin
Lowering plasma cholesterol and TG levels
This appears to be due to decreased TG synthesis
what do niacins do to LDL, HDL, triglycerides
↓ LDL-cholesterol by 5 – 25%
↑ HDL-cholesterol 15 – 35%
↓ Triglycerides by 20 – 50%
Statins DIs
- Erythromycin, clarithromycin, azithromycin (renal failure & pancreatitis)
- Azole antifungals
Anticoagulants
Certain antibiotics
metronidazole, tetracycline, erythromycin, clarithromycin
