CHF Flashcards
1
Q
3 targeting mechanisms of CHF tx
A
- Decreasing the cardiac workload
- Controlling excess fluid
- Enhancing Myocardial contractility
2
Q
what drugs decrease cardiac workload?
A
ACE Inhibitors
Angiotensin II receptors antagonists
3
Q
what drugs control excess fluid?
A
Diuretics
4
Q
what drugs enhance myocardial contractility?
A
Cardiac Glycosides (digoxin)
5
Q
MOA of digoxin
A
Inhibition of the Na+-K+- pump (Na+/K+ ATPase) –> increase in intracellular Na+ –> inhibitory effect on the non-enzymatic Na+/ Ca2+ exchanger –> increase in intracellular Ca2+
6
Q
AEs of digoxin
A
Gastrointestinal distress
Dizziness
Headache
Weakness
Syncope
Seizures
Confusion / Delirium / Hallucinations