CHF Flashcards

1
Q

3 targeting mechanisms of CHF tx

A
  1. Decreasing the cardiac workload
  2. Controlling excess fluid
  3. Enhancing Myocardial contractility
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what drugs decrease cardiac workload?

A

ACE Inhibitors
Angiotensin II receptors antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what drugs control excess fluid?

A

Diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what drugs enhance myocardial contractility?

A

Cardiac Glycosides (digoxin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA of digoxin

A

Inhibition of the Na+-K+- pump (Na+/K+ ATPase) –> increase in intracellular Na+ –> inhibitory effect on the non-enzymatic Na+/ Ca2+ exchanger –> increase in intracellular Ca2+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

AEs of digoxin

A

Gastrointestinal distress
Dizziness
Headache
Weakness
Syncope
Seizures
Confusion / Delirium / Hallucinations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly