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Hyperlipidaemia Flashcards

1
Q

First line medication for treating hypercholesterolaemia

A

Statins

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2
Q

What drug class is better at lowering triglyceride concentration than statins?

A

Fibrates

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3
Q

What drug can be added to statin therapy if TG remain high?

A

Fenofibrate

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4
Q

What heart condition are patient with familial hypercholesterolaemia at high risk of?

A

premature coronary heart disease

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5
Q

What should be offered to patients with familial hypercholesterolaemia?

A
  1. Statin therapy

2. Lifestyle advice

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6
Q

What is defined as a high intensity statin?

A

Where the reduction in LDL-cholesterol is greater than 40%

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7
Q

What should be offered to patients with primary heterozygous familial hypercholestererolaemia who are contra-indicated to be on a statin?

A

Ezemtibe monotherapy

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8
Q

If the maximum tolerated dose of statin fails to provide adequate control of LDL cholesterol what can be tried?

A
  1. Statin + Ezemtibe
  2. different statin
  3. bile acid sequestrant or fibrate (under specialist input)
  4. Evolocumab or Alirocumab
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9
Q

What is a side effect that could happen when being on a fibrate and a statin?

A

muscle related side effects ( Rhabdomyolysis risk)

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10
Q

Can Gemfibrozil be given with a statin?

A

No- considerable risk of Rhabdomyolysis

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11
Q

Examples of high intensity statins?

A

Atorvastatin (20mg, 40mg, 80mg)
Rosuvastatin (10mg, 20mg, 40mg)
Simvastatin (80mg)

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12
Q

Medium intensity statin examples

A

Atorvastatin (10mg)
Fluvastatin (80mg)
Rosuvastatin (5mg)
simvastatin (20mg, 40mg)

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13
Q

Examples of low intensity statins

A

Fluvastatin (20mg, 40mg)
Pravastatin (10mg, 20mg, 40mg)
Simvastatin (10mg)

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14
Q

MHRA adivce about simvastatin 80mg

A

High risk of myopathy associated wiht 80mg simvastatin. The 80mg dose should only be considered in patients with severe familial hypercholesterolaemia and high risk cardiovascular complications who have not reached their treatment goals on lower doses

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15
Q

Mechanism of action of bile acid sequestrants

A

bind to bile acid, preventing their absorption, this promotes hepatic conversion of cholesterol into bile acids; the resultant increased LDL-receptor activity of the liver cells increases the clearance of LDL cholesterol from the plasma

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16
Q

What needs to be noted about bile acid sequestrants affect on fat soluble vitamins?

A

BA sequestrants interfere with the absorption of fat soluble vitamins (ADEK and folic acid)

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17
Q

Examples of bile acid sequestrants

A

Colesevlam hydorchloride, Colestipol hydrochloride, Colestyramine

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18
Q

What needs to be monitored when a patient is on Colesevelam and ciclosporin?

A

Ciclosporin levels before, during and after treatment with colesevelam

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19
Q

What is the guidance for administration of Colestipol and can patients take other medications at the same time?

A

mix contents of each sachet with 100mL of water or other suitable liquid. Avoid other drugs at the same time

20
Q

What drug works by inhibiting the intestinal absorption of cholesterol?

21
Q

How does Benfibrate work?

A

Acts by decreasing serum triglycerides; they have a variable affect on LDL cholesterol

22
Q

What are the 2 reasons Benzafibrate may be stopped?

A
  1. mytotoxicity suspected

2. if CK level increases significantly

23
Q

How should Benzafibrate be taken?

A

Swallow whole with food

24
Q

What does reduction is required for Ciprofibrate in moderate renal impairment?

A

100mg on alternate days

25
What gastro-intestinal disorder are fibrates contra-indicated in?
Gall bladder disease
26
What is the monitoring requirement for Fenofibrate?
1. hepatic transaminases every 3 months during the first 12 months of treatment and periodically thereafter - discontinue if treatment levels increase to more than 3 times the ULN 2. serum creatinine levels during firs 3 months and periodically thereafter - interrupt treatment if creatinine levels is >50% of ULN
27
Examples of nicotinic acid derivatives
Nicotinic acid, Acipimox
28
Common side effect with nicotinic acid derviatives
Prostaglandin mediated flushing - typically within an hour of dosing and lasting for 15 - 30 mins ( particularly with the inital dose). Taking after aspirin or before food minimizes this
29
How do Statins work?
competitively inhibit 3-HMG CoA reductase and enzyme involved in cholesterol synthesis, especially in the liver
30
At what creatinine kinase concentrations are patients at risk of muscle effects?
5 times the ULN
31
If a patient developed myalgia and has a raised CK on a statin - wha does the BNF suggest to do?
Stop the statin. If symptoms resolve and CK comes back to normal can start a statin back at a lower dose. Statins should not be restarted if there is an increase in blood glucose conc as the benefits continue to outweigh the risks
32
If a patient has symptoms such as dysponea, cough and weight loss on a statin - what could this be?
Intersitual lung disease
33
How long is contraception needed during statin therapy?
Throughout therapy and for 1 month post
34
What patient population should statins be avoided in?
Pregnancy (discontinue 3 months before conception)
35
What blood monitoring is needed before statin statin therapy?
1. full lipid profile (non fasting) including total cholesterol, HDL, non HDL, TG 2. TFT 3. Renal function 4. LFTs - before and reeat within 3 monthd then annually 5. Creatine kinase - in patients who have persistant, generalised muscle pain 6. Blood glucose - patients who are at high risk of DM should have fasting glucose / HbA1c checked before starting and at 3 months
36
If a patient is on Ciclosporin therapy and needs to be started on atorvastatin - what is the maximum dose?
10mg OD
37
What is the maximum dose of atorvastatin when given alongside anion-exchange resin for heterozygous familial hypercholesterolaemia?
40mg OD
38
What is the maximum dose of atorvastatin + elbasvir/grazoprevir/sofosbuvir?
20mg OD
39
Maximum dose of Simvastatin + fibrate
10mg OD
40
Maximum dose of Simvastatin + amiodarone / amlodipine / ranolazine?
20mg OD
41
If simvastatin is given concurrently with CYP3A4 inhibitors e.g. Verapamil, what is the max recommended dose?
20mg OD
42
Which statin and what dose can be sold to the public to reduce the risk of first coronary event in individuals at moderate risk of CHD?
Simvastatin 10mg, 28 pack size
43
What drug class do Alirocumab and Evolocumab belong to?
PCSK 9 inhibitors Work by binding to pro-protein involved in the regulation of LDL receptors on liver cells; receptor numbers increase which results in increased uptake of LDL
44
How should Evolocumab be stored?
In fridge (2 - 8 degrees)
45
Which 2 statins need to be given at night?
Pravastatin and Simvastatin

BNF Cardiovascular (10 decks)

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