Bleeding disorders

Question 1

Example of a fibrinolysis inhibitor

Answer 1

Tranexamic acid

Question 2

Indications for TXA

Answer 2

Menorrhagia, trauma, epistaxis, hereditary angiodema

Question 3

Dose of tranexamic in menorrhagia

Answer 3

1g TDS for 4 days (max dose of 4g a day)

Question 4

Dose of tranexamic acid in epistaxis

Answer 4

1g TDS 7 days

Question 5

Common side effect from TXA

Answer 5

Diarrhea ( may need to reduce dose)

Question 6

Side effects of IV TXA

Answer 6

Hypotension, malaise (if rapidly injected)

Question 7

What organ should be monitored when on TXA

Answer 7

Liver - LFTS need to be carried out regularly in long term treatment

Question 8

Example of a biologic drug used in haemostasis

Answer 8

Emicizumab

Question 9

CCB used for SAH

Answer 9

Nimodipine

Question 10

Dose of Nimodipine in SAH

Answer 10

60mg 4 hourly within 4 days of hemorrhage and for 21 days in total

Question 11

What are nimodipine tablets sensitive to?

Answer 11

Light

Question 12

Two types of peripheral vascular disease

Answer 12

occlusive or vasospastic

Question 13

Whast drug can be given IV for patients who have critical limb ischaemia?

Answer 13

Illoprost