Hyperestrinism in Dog Flashcards
1
Q
Common causes hyperestrinism in Dogs
A
- Cystic ovaries
- dog goes into heat and doesn’t come out
- Granulosa cell tumores
- Sertoli Cell tumors
- all kinds can feminize male dogs
- Estrogen drugs
- menopause creams
2
Q
Clinical Signs hyerestrinism
A
- Vulvar edema +/- d/c
- Alopecia caudal trunk and perineum
- Epidermal hyperpigmentation
- Nipple enlargement
- Attractive to other dogs
3
Q
Hyperestrinism can cause _____
A
- Myelotoxicity
- anemia
- leukopenia
- thrombocytopenia
*get a CBC on these dogs
4
Q
Hyperestrinism TX
A
- Spay
- remove drugs
5
Q
Consequences of myelotoxicity
A
- No white cells => infection
- No platelets => bleed
- No RBCs => tissue oxygen deprivation
6
Q
Pale patechia
A
- could be an anemic TCP
7
Q
Prognosis and TX pancytopenia
A
- Bone marrow bx to prognose
- no precursor cells (aplastic) => grave sign
- give blood products, Neupogen, Epogen
- remove source of estrogen
- no precursor cells (aplastic) => grave sign
8
Q
Take home message
Hyperestrinism in female
A
- Often due to cystic ovaries
- Alopecia posterior and ventral
- vulvar enlargement and serosanguineous discharch
- OHE
- Neupogen and Epogen for myelotoxicosis
9
Q
3 cell types of testicular tumors
A
- Sertoli
- can metastasize and feminize
- Seminoma
- can metastasize and feminize
- Interstitial (Leydig)
- mets rare, feminization rare
10
Q
Incidence of sertoli cell neoplasia
A
- 3-20 yrs old (ave 8-9)
- Dogs with extrascrotal involvement with feminization may present at a younger age than dogs with scrotal involvement
- intraabdominal have higher rate of feminization
11
Q
Site of involvement
A
- Usually unilateral
- Right cryptorchid teste common
- 30-40% are extrascrotal
- inguinal
- abodminal
12
Q
Clinical signs of Feminization
A
- Prostatic changes: metaplasia, infection => obstruction, cysts
- Atrophy of contralateral testicle => one in scrotum usually small
- Symmetrical alopecia
- Gynecomastia => breat development
- Pendulous prepuce
- Tendency to attract other male dogs
- depressed libido
- lethargy
13
Q
Prostatic carcinomas like to met to ____
A
Ventral vertebral bodies
14
Q
Sertoli cell tumors act like _____
A
Carcinomas
15
Q
Take home message
Sertoli Cell:
A
- Feminization is a sentinel
- All 3 tumor types in all 3 locations can cause feminization
- Assess for myelosuppression
- Asses for prostatic infection