Hypercoagulability Flashcards
What is Virchow’s triad?
It identifies the three underlying factors that contribute to thrombosis
What are the 3 pillars of virchow’s triad?
Hypercoagulability, stasis, and endothelial injury
What are the causes of hypercoagulability?
Antithrombin deficiency, Protein C/S deficiency
What is associated with a risk of DVT?
Thrombophilia (ease of blood forming clots)
Protein C/S and antithrombin 3 deficiencies are associated with what type of thrombosis?
Arterial thrombosis
What do we suspect in a person younger than 40 experiencing a DVT?
Hereditary thrombophilia
Lupus anticoagulants, which are antiphospholipid antibodies, occur in who?
20% of SLE patients
What is Antiphospholipid syndrome? (APS)
An acquired autoimmune disorder that presents as a recurrent DVT or arterial thrombosis
What is venous thromboembolic disease?
Most commonly occurs during or right after hospitalization, treated with prophylaxis
When does DVT cause death?
When there’s a massive PE
What are the signs of DVT?
Edema most specially, and leg pain
What is Homan’s sign?
Calf pain upon dorsiflexion of the foot? A sign of DVT.
What are the lab tests for DVT?
CRP, D-dimer, AT3, and coagulation studies
What’s the imaging of DVT?
Ultrasonography
What’s an IPG?
Impedance plethysmography, non-invasive measurement of electrical resistance in the calves
