Aplastic Anemia Flashcards
1
Q
What is Aplastic anemia?
A
Bone marrow failure, thus pancytopenia develops
2
Q
What’s the most common pathogenesis of aplastic anemia?
A
Autoimmune suppression of hematopoiesis by T cell mediated mechanism
3
Q
Defects in DNA repair pathways lead to?
A
Fanconi anemia
4
Q
What is the hallmark lab finding of aplastic anemia?
A
Pancytopenia
5
Q
Symptoms of aplastic anemia?
A
Cold extremities, pallor, shortness of breath? Weakness fatigue
6
Q
How do we diagnose aplastic anemia?
A
Pancytopenia confirmation, hypocellular bone marrow and ensure no abnormal hepatopoietic stem cells seen in blood
7
Q
How do we treat severe aplastic anemia?
A
Immediate transfusions, and broad spectrum anti-biotics
8
Q
The only curative treatment for SAA (severe aplastic anemia is?)
A
Transplantation
