[HYHO] HPS Session 2 AKI Flashcards
What is the definition of acute kidney injury?
Increase in serum creatinine of greater than or equal to 0.3mg/dL within 48 hours
OR
Urine output of <0.5mL/kg/hour for >6 hours
What is cardiorenal syndrome?
A condition which therapy to relieve congestive symptoms of HF is LIMITED by a decline in renal funciton
How is GFR calculated?
Using creatinine
What is an issue with using creatinine to measure GFR?
Can UNDERESTIMATE the degree of dysfunction
What are the 3 potential causes for AKI?
Prerenal
Intrinsic
Postrenal
What are the potential causes of prerenal AKI?
Hypovolemia
Decreased cardiac output
Decreased effetive circulating volume
Impaired renal autoregulation
What are the causes of intrinsic AKI?
Glomerular
Tubules/Interstitum
Vascular
What are the causes of postrenal AKI?
OBSTRUCTION
(e.g. bladder outlet obstruction, pelvourethral obstruction)
What is key to determining the source of an AKI?
Careful history taking
What is a common example of an event in the hx. of a patient that can present with AKI?
Exposure to IV contrast
Typically increases serum creatinine (25-50%) after administration
Describe what the symptom correlates with:
Blue toes
Possible cholesterol emboli
Describe what the symptom correlates with:
Appearance of ‘drug rash’
Acute Interstitial Nephritis (AIN)
Describe what the symptom correlates with:
Signs of volume contraction (tachycardia, skin tenting, dry oral mucosa, etc…)
Dehydration
Describe what the symptom correlates with:
Jaundice and ascites
Liver disease with portal hypertension
What are the symptoms/signs associated with AKI?
Decreased urine output
Worsening dyspea
Orthopnea
Paroxysmal nocturnal dyspnea
Worsening edema
S3 gallop
Hypotension
JVD
Liver distention
Distended abdomen (fluid wave)
Where is skin testing best evaluated?
Skin of the forehead