Hungtingtons Disease Flashcards
0
Q
S + S?
A
Prodrome phase - irritability, depression, in coordination
Progresses to chorea, dementia.
Westphal variant - specific type of chorea in younger patients
1
Q
What is HD?
A
Inherited neuro degenerative disorder.
Affects 40 year olds. Juvenile is considered onset before 20.
Autosomal dominant
2
Q
Ix?
A
Genetic testing for CAG repeats > 40.
MRI brain
- ventricle enlargement
3
Q
Rx?
A
Non-pharm
MDT
PHARM
- chorea: tetrabenazine, haloperidol, pimozide
- neuropsychiatric - antipsychotics
