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Immunology > Humoral system > Flashcards

Humoral system Flashcards

1
Q

What is the structure of IgG?

A

Monomer

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2
Q

What is the structure of IgA?

A

Dimer

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3
Q

What is the structure of IgM?

A

Pentamer or Monomer

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4
Q

What is the structure of IgE?

A

Monomer

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5
Q

What is the structure of IgD?

A

Monomer

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6
Q

Which the most abundant antibody?

A

IgG

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7
Q

Which is the largest antibody?

A

IgM

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8
Q

Which antibody crosses the placenta?

A

IgG

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9
Q

Which antibody is transferred in breast milk?

A

IgA

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10
Q

Where is IgM found?

A

It is the first responder in primary immune response. Released by plasma cells

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11
Q

Which antibodies activate the classical pathway of the complement system?

A

IgG and IgA

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12
Q

Which antibodies are involved in type 2 hypersensitivity reaction?

A

IgG and IgA

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13
Q

Which antibody is involved in type 1 hypersensitivity reaction?

A

IgE

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14
Q

Which antibody is a pentamer?

A

IgM

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15
Q

Where is IgD found?

A

Transmembrane antibody found on plasma cells

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16
Q

Where is IgA found?

A

Breast milk, GI mucosa, urogenital system, sweat, saliva

17
Q

Where is IgE found?

A

Respiratory tract mucosa, lymphatic tissue, gi mucosa, urogenital system

18
Q

Which cells does IgE act on?

A

Causes degranulation of mast cells to release histamine (type 1 hypersensitivity reaction)

19
Q

What is the Fab region?

A

Antigen binding fragment = made up of 1 light chain variable region and 1 heavy chain variable region

20
Q

Which section on an antibody binds to antigens?

A

Variable light and heavy chains = antigen binding region (fab)

21
Q

What is the Fc region of the antibody?

A

Constant fragment = heavy and light constant chains - binds to complement proteins

22
Q

How are heavy and light chains held together?

A

With di-sulphide bonds

23
Q

What kind of molecule is an antibody?

A

A glycoprotein

24
Q

What is humoral immunity?

A

Immunity mediated by antibodies rather than cell mediated immunity

Immunology (6 decks)

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