Cell mediated immunity

Question 1

What are MHCs?

Answer 1

Major Histocompatability complexes are proteins on the cell surface that present antigens

Question 2

Where is the gene for MHC located?

Answer 2

Short arm of chromosome 6

Question 3

Where are MHC class 1 found?

Answer 3

Expressed on all nucleated cells

Question 4

Which proteins make up the MHC class 1?

Answer 4

HLA- A, HLA -B, HLA-C

HLA-E, HLA-F, HLA-G

Question 5

Which MHC is found on the placenta?

Answer 5

Predominately HLA-G

Also HLA-C, HLA-E, HLA-F

Question 6

Which MHC class is suppressed in pregnancy?

Answer 6

MHC class II

Question 7

Which proteins make up MHC class II?

Answer 7

HLA-DR, HLA-DQ, HLA-DP

Question 8

Where are MHC class II proteins expressed?

Answer 8

On antigen presenting cells

Question 9

What are the specialised antigen presenting cells?

Answer 9

Macrophages, dendritic cells, B cells

Question 10

Which cells are leucocytes derived from?

Answer 10

Myeloid progenitor cells

Question 11

What is the role of CRP?

Answer 11

An acute phase serum protein that coats pathogens to promote opsonization

Question 12

Where is CRP produced?

Answer 12

In the liver

Question 13

How does sickle cell disease alter ESR levels?

Answer 13

They decrease

Question 14

How does heart failure alter ESR levels?

Answer 14

They decrease

Question 15

How does Polycythaemia alter ESR levels?

Answer 15

They decrease

Question 16

What kind of molecule is a cytokine?

Answer 16

A glycoprotein

Question 17

Which cytokines are produced by Th1 cells?

Answer 17

IFN-gamma and IL2

Question 18

Which type of immunity do Th1 cells promote?

Answer 18

Cell mediated immunity via macrophages and CD8 cells

Question 19

Which type of immunity do Th2 cells promote?

Answer 19

Humoral immunity via B lymphocytes

Question 20

Which cytokines promote Th1 cell development?

Answer 20

IFN-gamma and IL2

Question 21

Which cytokine promotes Th2 cell development?

Answer 21

IL-4

Question 22

Which MHC do T-helper cells act on?

Answer 22

MHC-2

Question 23

Which T-helper cells are promoted in pregnancy?

Answer 23

Th 2 - humoral immunity

Question 24

Which T helper cells are down-regulated in pregnancy?

Answer 24

Th-1 cell mediated immunity

Question 25

Which cytokine is suppressed by HLA-G in pregnancy?

Answer 25

IFN-gamma (a Th1 promoter)

Question 26

Which pathogens do eosinophils attack?

Answer 26

parasites

Question 27

Which MHC does NK cells bind to?

Answer 27

MHC-1

Question 28

Which cytokines stimulate NK cells?

Answer 28

IL-1 and IFN-gamma