human herpevirus Flashcards
What is the structure of herpes virus
has an icosahedral capsid, glycoproteins inserted in envelope, dsDNA
what is required for control of herpes viruses
cell mediated immunity
where does lytic infection of herpes tend to present
mucoepithelial cells
where does latent infection of herpes tend to present
neuron
What are some local symptoms of herpes
pain, itching, dysuria, malaise, fever, headache
What are some systemic symptoms of herpes simplex virus
wet ulcer, crust, vesicle (lesions)
tender lymph nodes
Where is the site of viral latency for primary herpes gingivostomatitis
trigeminal ganglia
What are some clinical syndromes of herpes simplex virus
- mucocutaneous (gingivostomatitis, cold sores)
- herpetic keratitis
- herpetic whitlow
- genital herpes
- herpes encephalitis
- neonatal herpes
What lab diagnostic technique do you use to detect
immunofluorescence, or virus isolation, or PCR
How can you treat herpes simplex virus, and how does the drug work
acyclovir. Phosphorylation by viral thymidine kinase activate the drug, prevent elongation of viral DNA synthesis
How does varicella zoster spread
through contact or respiratory droplet, infection of mucosa of upper respiratory tract
What does epstein-barr virus affect
B lymphocytes. prolifereates in epithelial cells and B cells, immortalises B cell
What is the proliferation of Epstein-barr virus controlled by
T cell
What does EBV cause
asymptomatic shedding, pharyngitis, infectious mononucleosis, african burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma, ebv-induced lymphoproliferative disease in post transplant and HIV. Hairy oral leukoplakia
what are the treatment for Epstein Barr virus
no effective treatment or vaccine
which is one part of the body that epstein- barr virus can be found
in saliva
how can cytomegalovirus present itself
CMV retinitis especially in patients with AIDS. CMV pneumonitis after renal transplantation
How to treat CMV
no vaccine, treatment: ganciclovir, foscarnet, cidofovir
How to prevent CMV
screen organ transplant donors, supply leucocyte depleted blood
what is the incubation period of EBV
up to 2 months
what is the incubation for herpes virus, and how long does the virus sheds for
5days incubation, shed for around 15 days
who does CMV present itself in
post transplant patient
hiv patients–> retinitis and encephalitis and disseminated disease
pregnancy —> fetal infection affecting pain and multiple organs
