enterovirus Flashcards
features of enterovirus
- small virus (25-30nm in diameter)
- icosahedral capsid
- positive sense, single stranded RNA
- no envelope
- very resistant to harsh environnment
-cytolytic
where does human rhinovirus bind to
ICAM-1 surface receptor on host cell
How does transmission of enterovirus occur
through faecal oral route or respiratory route
how does HPV look
non enveloped, dsDNA
what does HPV do
infect basal layer of the surface epithelia and produce warts at site of multiplication on skin or mucus membrane
what is HPV responsible for
etiological agents of several benign tumours like cutaneous genital warts and respiratory papillomas and cervical cancer
Which HPV is responsible for majority of cervical cancer
HPV 16 and 18
How are HPV transmitted
sexual intercourse, skin abrasion, oral sex, through birth canal
What kind of HPV are ther
Mucosal HPV and cutaneous HPV, recurrent respiratory papillomatosis
What HPV causes oral cavity wart
HPV 6 and 11
What are some HPV vaccines
cervavix bivalent (for HPV 16,18) primarily to prevent cervical cancer
gardasil (quadrivalent vaccine for HPV 6,11,16,18)
What are some symptoms of recurrent repiratory papillomatosis
vocal cord affected, may cause respiratory disease and obstruction
how does the HPV vaccine work
Major viral protein L when expressed as a recombinant protein could self assemble into viral like protein that results in a high titer type specific antibody response
