Human Development: Chapter 7-8 Flashcards
Embryonic period of development
Takes place over the first 8 weeks, or ⅔ of the first trimester
- cells divide and become redistributed
- tissues and organs form
- structures that support and nourish the developing embryo form
Fetal period of development
Takes place from the start of the ninth week through birth, or the remaining third and second
and third trimesters
- body grows rapidly
- organs begin to function and coordinate to form organ systems
Fertilization
Joining of male and female gametes (sperm and egg cell) to form a cell (zygote). This cell will have 46 chromosomes, 23 from the sperm, 23 from the egg. (23 chromosome pairs)
Female preparation for fertilization
- Egg is released from an ovary and is swept into an oviduct
- Egg is carried to the uterus by muscular contractions and wavelike actions of cilia that line the oviduct. (Takes about 4 days, and the egg must be fertilized within 12 to 24 h of its release in order to develop further)
Male preparation for fertilization
Several hundred million sperm cells exit male’s urethra during ejaculation
Once sperm enters the vagina, they must go through the cervix, uterus, and oviduct where the egg is. (Most sperm does not survive, some are destroyed in the vagina’s toxic environment, some go through the wrong oviduct.)
Egg structure
The plasma membrane of the egg is surrounded by zona pellucida (thin layer of protein and carbohydrate). The zona pellucida is surrounded by the corona pellucida (several jelly-like layers of follicle cells that loosely adhere to one another. Follicle cells were a source of nourishment for the egg when it was an ovarian follicle.)
Fertilization process and formation of a zygote
When the sperm meets the corona radiata, the sperm’s enzyme-containing acrosome (“cap” around the nucleus) releases its contents
Enzymes digest their way through the corona and zona pellucida. (Many sperms are required for this activity.) The sperm advances further by lashing of its tail.
Once a sperm enters the egg, the egg’s plasma membrane depolarizes, preventing other sperm from binding with and entering it.
Within 12 h of the sperm’s nucleus entering the egg, membranes of sperm nucleus and egg nucleus disappear. 23 chromosomes in the ovum join with the 23 chromosomes in the sperm.
Fertilization is now complete and a zygote is formed.
Zygote
A cell formed by the union of two gametes; the product of fertilization; has 23 pairs of chromosomes (making a total of 46 chromosomes)
Polyspermy and prevention
When an egg is fertilized by more than one sperm
→ prevention: when one sperm enters the egg, the egg’s plasma membrane depolarizes,
preventing other sperm from with and entering it
Cleavage
The process of cell division without cell growth
30h of fertilization: the 0.1mm zygote divides by mitosis for the first time, making two new cells. These cells divide, making four, then eight, then so on. (Cells get smaller each division, so zygote remains about 0.1mm.)
Morula
Sphere zygote made of 16 cells.
- Reaches uterus within 3-5 days of fertilization
- Begins to fill with fluid that diffuses from the uterus. As the fluid-filled space develops, two different groups of cells form, creating a blastocyst
Blastocyst
(Greek: “germ pouch”) Mammalian embryo at the stage in which it is implanted in the wall of the uterus and consists of a nearly hollow ball of cells; is made up of two groups of cells: the trophoblast and inner cell mass.
Trophoblast
(“Nourishment of the germ”) A group of cells that forms the outer layer of the blastocyst
- Will develop into a chorion
Chorion
(“Membrane”) Develops from a trophoblast, and develops into the placenta
Placenta
Structure that provides nutrients and oxygen to, and removes wastes from, the developing offspring.
Inner cell mass
(or embryoblast) The other group of cells of the blastocyst. Will develop into the embryo.
Implantation
The process of attachment of the embryo to the endometrium
→ between the fifth and seventh day after fertilization, blastocyst attaches itself to the
endometrium (lining of the uterus), with the inner cell mass against the endometrium.
→ trophoblast secretes enzymes that digest some of the tissues and blood vessels of the endometrium, and the blastocyst slowly sinks into the uterine wall
- Implantation is completed by the tenth or fourteenth day. The woman is technically pregnant after implantation.
Human chorionic gonadotropin (hCG)
Hormone secreted by the trophoblast at the time of implantation of the embryo; prevents degeneration of the corpus luteum.
- same effects as luteinizing hormone (LH)
- secretes estrogen and progesterone, maintaining endometrium and preventing menstruation
→ hCG secretion continues at a high level for two months, then declines to low at the end of
four months, as the corpus luteum is less important as a source of hormones after the first trimester. (By now, the placenta secretes enough estrogen and progesterone to maintain endometrium.)
Corpus luteum
Yellow-ish, gland-like structure that develops from a follicle that has matured and released its egg (ovum); it produces progesterone and some estrogen; if pregnancy doesn’t occur, it degenerates
Gastrulation
The formation of the three primary germ layers in embryogenesis.
→ Once implantation finishes, inner cell mass changes. Space forms between the inner cell mass and the trophoblast called the amniotic cavity. (Will fill with fluid and is the location where baby will develop) Amniotic cavity forms within a sac called the amnion.
→ Inner cell mass flattens into a disk-shaped structure called the embryonic disk which is
supported by a short stalk that connects blastocyst with the endometrium
→ Embryonic disk is consisted of two layers: outer ectoderm (closer to amniotic cavity) and inner endoderm. A third layer forms between the endoderm and ectoderm, and is called the mesoderm.
- Creates a gastrula
Primary germ layers
The embryonic disk’s layers. Includes outer ectoderm, inner endoderm, and the mesoderm between both.
Embryonic disk is consisted of two layers: outer ectoderm (closer to amniotic cavity) and inner endoderm. A third layer forms between the endoderm and ectoderm, and is called the mesoderm. (This process is gastrulation)
Differentiation
Cellular process that enables a cell to develop a particular shape and to perform specific functions that are different from the functions of other cells. (Cells, tissues, and organs of the body are derived from the primary germ layers through differentiation.)
Morphogenesis
Series of events that form distinct structures of the developing organism. Derives from differentiation.
What does the ectoderm (outer layer) turn into?
- outer skin (epidermis) and associated structures (hair, - - nails, sweat glands, mammary gland)
- nervous tissue and sense organs
- pituitary gland
- tooth enamel
- adrenal medulla
- eye lens
What does the mesoderm (middle layer) turn into?
- dermis of skin
- cellular lining of blood vessels, lymphatic vessels, body cavities
- muscle tissue
- connective tissue (including bone, cartilage, blood)
adrenal cortex - kidneys and ureters
- heart
- spleen
- internal reproductive organs
What does the endoderm (inner layer) turn into?
- cellular lining of respiratory tract, digestive tract, urinary bladder, urethra
- liver (most)
- tonsils (partial)
- gallbladder
- parathyroid glands
- pancreas
- thyroid glands
- thymus
Neurulation
in embryogenesis, the process of forming the neural tube, which develops into the brain and spinal cord
→ During the third week, a thickened band of mesoderm cells develops along the back of the embryonic disk. This will become the baby’s back and come together to form a rod-like structure called the notochord
→ Notochord will form the basic framework of the skeleton
→ Nervous system develops from the ectoderm that is located just above the notochord
→ Cells along the surface of the notochord begin to thicken. Folds develop on each side of a groove along this surface. When these folds fuse, they become the neural tube, that develops into the brain and spinal cord
→ Marks the beginning of organ formation.
Third week into fertilization
Neurulation, and reddish bulge that becomes the heart. By the 18th day, heart starts beating.
Fourth week into fertilization
Embryo is about 0.6cm long)Rapid growth and development. Blood cells form and fill developing blood vessels. Lungs and kidneys that shape. Small buds (what will be arms and legs) appear. Distinct head, eyes, ears and nose.
Fifth week into fertilization
(~1.3cm) Embryo’s head is large compared to its body. Eyes open, but no eyelids or irises. Cells in brain are differentiating quickly.
Sixth week into fertilization
Brain develops rapidly. Limbs lengthen and flex slightly. Gonads produce hormones that will influence development of external genitalia.