Human Coxsakieviruses Flashcards
1
Q
Classification
A
Family: Picornaviridae
Genus: Enterovirus
Species:
Coxsackie virus group A
Coxsackie virus group B
2
Q
Characteristics
A
- Naked nucleocapsid
- +ssRNA
- No virion polymerase —> uses host machinery to replicate
- cytoplasmic replication
Group A and B viruses are defined by their different pathogenicity in mice
> there are multiple serotypes in each group
3
Q
Transmission
A
Fecal-oral route
4
Q
Pathogenesis
A
- Oropharynx: initial site of infection
- GIT: main site of infection
> the virus spreads through the bloodstream to various organs
5
Q
Diseases
A
- Aseptic meningitis: A
- hand, foot and mouth disease = red vesicular rash: A
- Herpangina: A
- Pleurodynia = Devil’s Grip, Bornholm disease: B
- Dilated Myocarditis in neonates and young children: B
- Pericarditis in young adults: B
6
Q
Microbiological diagnosis
A
- Detection»_space;» CPE in cell culture
- identification»_space;» serologic test: neutralisation
- diagnosis»_space;»a significant rise in antibody titer in convalescent-phase serum
7
Q
Treatment and prevention
A
Treatment:
- no antiviral therapy
- supportive therapy available
Prevention:
- no vaccine
