H.pylori Flashcards

1
Q

What is dyspepsia?

A

Group of symptoms describing bad digestion

eg. abdo discomfort, retrosternal pain, anorexia, nausea, vomiting, bloating, fullness, early satiety, heartburn

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2
Q

Investigations for dyspepsia presentation? (4)

A

History + exam
Bloods
Drug history
Lifestyle

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3
Q

When to refer for endoscopy for dyspepsia?

A

ALARM symptoms

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4
Q

What is H.pylori?

A

Gram negative, spiral-shaped, microaerophilic, flagellated

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5
Q

What is the only thing H.pylori can colonise?

A

Gastric type mucous (acidic environment)

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6
Q

What is involved in non-invasive diagnosis of H.pylori? (3)

A

Serology - IgG against H.pylori
Urea breath tests
Stool antigen tests - ELISA (must be off PPI for 2 weeks)

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7
Q

What is involved in invasive diagnosis of H.pylori? (3)

A

Histology (gastric biopsies stained for bacteria)
Culture of gastric biopsies
Rapid slid urease test (CLO)

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8
Q

What is the main failure of eradication therapy? (2)

A

Resistance to antibiotics & poor compliance

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