HPV Related Cancers

Question 1

How many HPV viruses are there?

Answer 1

Over 200

Question 2

What does High or Low risk mean?

Answer 2

Risk for cancer

Question 3

Most common soft tissue, usually solitary, arising from the soft palate, exophytic with fingerlike projections

Answer 3

Squamous Papilloma

Question 4

Treatment for Squamous papilloma

Answer 4

Conservative excision, with low recurrence

Question 5

What is the name of the common wart which is contagious

Answer 5

Verruca vulgaris

Question 6

Location of oral verruca vulgaris

Answer 6

usually vermilion border, labial mucosa or anterior tongue

Question 7

Treatment for verruca vulgaris

Answer 7

Topical therapies, or surgery to remove them. They may recur, spontaneous remission is also possible

Question 8

What is the most common STI in the US?

Answer 8

HPV

Question 9

Low risk HPV’s (2 types)

Answer 9

6 and 11

Question 10

High risk HPV’s (2 types)

Answer 10

16 and 18

Question 11

Condyloma Acuminatum is similar to squamous papilloma, but how does it differ?

Answer 11

May have a co-infection with a high risk type and usually multiple lesions

Question 12

What is another name for condyloma acuminatum?

Answer 12

Venereal warts

Question 13

Anogenital condylomata infected with HPV 16 or 18 has a higher risk of what?

Answer 13

Malignant transformation to SCC

Question 14

HPV infects which layer/cells?

Answer 14

Basal cells

Question 15

What proteins do High Risk HPV types make?

Answer 15

E6, E7, L1, and L2

Question 16

What do the proteins E6 and E7 do?

Answer 16

Allow uncontrolled cell growth

Question 17

What do the proteins L1 and L2 do?

Answer 17

Allows for virus transmission spread and survival (virus capsid)

Question 18

Location differentiated between oral and oropharyngeal cancer

Answer 18

Anterior to tonsillar pillars is oral

Question 19

Most oropharyngeal SCC are what HPV type?

Answer 19

HPV 16

Question 20

OSCC has a much lower survival rate than

Answer 20

OPSCC

Question 21

How do you diagnose OPSCC?

Answer 21

E6 and E7 must be present in tumor cells AND serum presence of antibodies, not just presence of HPV 16

Question 22

HPV + and non smoker is best prognosis, what is the worse prognosis?

Answer 22

HPV- and smoker

Question 23

HPV is a vaccine against what?

Answer 23

Cancer, and only the HPV types it is built for

Question 24

Which HPV vaccine is available in the US?

Answer 24

Guardasil 9 (9 valent)