HPV Related Cancers Flashcards
How many HPV viruses are there?
Over 200
What does High or Low risk mean?
Risk for cancer
Most common soft tissue, usually solitary, arising from the soft palate, exophytic with fingerlike projections
Squamous Papilloma
Treatment for Squamous papilloma
Conservative excision, with low recurrence
What is the name of the common wart which is contagious
Verruca vulgaris
Location of oral verruca vulgaris
usually vermilion border, labial mucosa or anterior tongue
Treatment for verruca vulgaris
Topical therapies, or surgery to remove them. They may recur, spontaneous remission is also possible
What is the most common STI in the US?
HPV
Low risk HPV’s (2 types)
6 and 11
High risk HPV’s (2 types)
16 and 18
Condyloma Acuminatum is similar to squamous papilloma, but how does it differ?
May have a co-infection with a high risk type and usually multiple lesions
What is another name for condyloma acuminatum?
Venereal warts
Anogenital condylomata infected with HPV 16 or 18 has a higher risk of what?
Malignant transformation to SCC
HPV infects which layer/cells?
Basal cells
What proteins do High Risk HPV types make?
E6, E7, L1, and L2
What do the proteins E6 and E7 do?
Allow uncontrolled cell growth
What do the proteins L1 and L2 do?
Allows for virus transmission spread and survival (virus capsid)
Location differentiated between oral and oropharyngeal cancer
Anterior to tonsillar pillars is oral
Most oropharyngeal SCC are what HPV type?
HPV 16
OSCC has a much lower survival rate than
OPSCC
How do you diagnose OPSCC?
E6 and E7 must be present in tumor cells AND serum presence of antibodies, not just presence of HPV 16
HPV + and non smoker is best prognosis, what is the worse prognosis?
HPV- and smoker
HPV is a vaccine against what?
Cancer, and only the HPV types it is built for
Which HPV vaccine is available in the US?
Guardasil 9 (9 valent)
