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Oral Path 2 Final Exam > Developmental And Immune Mediated Mucocutaneous Conditions > Flashcards

Developmental And Immune Mediated Mucocutaneous Conditions Flashcards

1
Q

What are the 2 other names of Erythema Migrans?

A

Geographic tongue, Benign Migratory Glossitis

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2
Q

What causes erythema migrans and how common is it?

A

Probably immune mediated, 1-3 % of the population

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3
Q

What is the erythema of erythema migrans caused by?

A

Atrophy of filiform papillae and shearing of parakeratin.

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4
Q

What is it called when you have geographic tongue somewhere other than the dorsal aspect of the tongue?

A

Ectopic erythema migrans

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5
Q

Treatment for geographic tongue

A

None needed, occasionally if painful with foods can be treated with potent topical steroids.

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6
Q

Which type of lichen planus resolves after 7-10 years?

A

Cutaneous, mucosal is more chronic.

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7
Q

Wickham’s striae and purple polygonal pruritic papules are clinical features of which immune mediated condition?

A

Lichen Planus

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8
Q

What are the two oral forms of lichen planus?

A

Reticular (lacy white lines) and erosive (erythematous, may ulcerate)

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9
Q

Clinical features of Oral Lichen Planus

A

Reticular LP (white lines), ELP, bilateral buccal mucosa, tongue, gingiva common but any intraoral surface and lips.

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10
Q

Oral lichen planus has a malignant transformation. T/F

A

False, there is controversy over this, it is probably something else that turns malignant

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11
Q

What is the first thing to do if you find Oral Lichen planus?

A

Rule out candidiasis

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12
Q

How do you treat Erythematous Oral Lichen Planus

A

Potent Topical steroid “off Label”

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13
Q

What is it called when something appears to be lichen planus but is caused by something else?

A

lichenoid—amalgam reaction, drug reaction, mucositis etc

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14
Q

Most common collagen vascular/connective tissue disease in U.S.

A

Lupus erythematosus

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15
Q

what are the 3 forms of Lupus Erythematous

A

Chronic Cutaneous Lupus Erythematous, Systemic Lupus Erythematosus, Subacute cutaneous lupus erythematosus

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16
Q

Clinical Features of Chronic Cutaneous Lupus Erythematosus

A

Skin-scaly erythematous patches, heal then reappear, scars. Lichenoid mucositis

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17
Q

Malar “butterfly rash” is associated with?

A

Systemic Lupus Erythematosus

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18
Q

What are the 2 involvements you should be worries about with systemic lupus?

A

Renal and cardiac involvement

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19
Q

Rare condition characterized by inappropriate deposition of dense collagen

A

Systemic Sclerosis

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20
Q

Hard smooth texture of skin, raynaud phenomenon, sclerodactyly, acro-osteolysis, mask like face, atrophy of alae, mouse facies, dysphagia are all clinical features of what?

A

Systemic Sclerosis

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21
Q

Discoloration of the fingers or toes after exposure to changes in temperature or emotion events

A

Raynaud’s phenomenon

22
Q

resorption of posterior ramus, diffuse widening of PDL and possibly root resorption are radiographic features of what?

A

Systemic sclerosis

23
Q

Most deaths of systemic sclerosis are due to what?

A

deposition of collagen on internal organs

24
Q

Systemic sclerosis prognosis, limited cutaneous involvement is better/worse than diffuse cutaneous involvement

A

Better

25
Q

What does CREST syndrome stand for?

A

Calcinosis cutis, Raynaud’s phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasia-These are a milder version of systemic sclerosis

26
Q

Is CREST syndrome better or worse than systemic sclerosis?

A

Better than sclerosis

27
Q

Group of inherited disorders in which two or more ectodermally derived structures do not develop normally or fail to develop

A

Ectodermal dysplasia

28
Q

Hypohidrotic ectodermal dysplasia is what?

A

Heat intolerance in ectodermal dysplasia-I’m not actually sure.

29
Q

In what disease do autoantibodies destroy desmosomes?

A

Pemphigus vulgaris

30
Q

Pemphigus Vulgaris has (oral or body) lesions that are “first to show, last to go”?

A

Oral

31
Q

What is a nikolsky sign and what does it indicate?

A

Inducing a bulla by applying firm lateral pressure on skin, indicates Pemphigus Vulgaris

32
Q

which immunofluorescence is used to detect antibodies in tissues?

A

direct

33
Q

which immunofluorescence is used to detect antibodies in blood?

A

indirect

34
Q

treatment for pemphigus vulgaris

A

systemic corticosteroids

35
Q

prognosis of pemphigus vulgaris

A

prior to therapy, 60-90% mortality, 5-10% after treatment

36
Q

mucous membrane pemphigoid more or less common than pv

A

more, 2x

37
Q

would you see intraoral intact blisters in mucous membrane pemphigoid or pemphigus vulgaris?

A

MMP

38
Q

Clinical features of Mucous Membrane pemphigoid

A

desquamative gingivitis

39
Q

Scarring involvement of the symblepheron in the eye is the most significant aspect of which condition?

A

Mucous Membrane Pemphigoid

40
Q

Mucous Membrane Pemphigoid is positive or negative DIF and IIF?

A

Positive DIF and Negative IIF

41
Q

Treatment for Mucous membrane Pemphigoid

A

Topical steroids-frequent dental prophylaxis and refer to opthalmologist

42
Q

Prognosis for Mucous Membrane Pemphigoid

A

Rarely fatal, blindness can result

43
Q

What is the most common of autoimmune blistering conditions?

A

Bullous Pemphigoid

44
Q

Bullous Pemphigoid is positive or negative IIF and DIF

A

Positive to both

45
Q

Treatment for Bullous Pemphigoid

A

Usually resolves within 2 years

46
Q

Acute onset of ulcerative disorder skin and mucous membranes

A

Erythema Multiforme

47
Q

When is erythema multiforme considered major?

A

2 or more mucosal sites in conjunction with skin lesions

48
Q

Stevens-JOhnson syndrome

A

at least 2 mucosal sites plus skin involvement (<10%)

49
Q

Toxic epidermal necrolysis

A

Diffuse bullous involvement of skin and mucosa (>30%)

50
Q

Stevens-Johnson syndrome and Toxic epidermal necrolysis are almost always triggered by what?

A

a Drug

51
Q

Treatment for EM

A

Discontinue the problem drug, steroids, analgesics

52
Q

What should be avoided in management of Toxic Epidermal Necrolysis?

A

Steroids

Oral Path 2 Final Exam (5 decks)

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