HPA drugs Flashcards
Pseudotumor cerebri, slipped capital femoral epiphysis, scoliosis, edema, hyperglycemia, asphyxiation in severely obese patients with Prader-Willi syndrome
Patients with turner syndrome risk of otitis media
Pancreatitis, gynecomastia, and nevus growth
Peripheral edema, myalgia, and arthralgia
SE of GH
Recombinant Human IGF-1
given when IGF-1 issue with receptor of GH
Hypoglycemia
Intracranial hypertension, lipohypertrophy, elevation of liver enzymes
SE of recombinant human IGF-1
sermorelin
somatropin
GH
Octreotide, Lanreotide
Somatostatin analogs
Pegvisomant
Growth hormone receptor antagonist
Nausea, vomiting, abdominal cramps, flatulence, steatorrhea, biliary sludge, gall stones, hypertension, peripheral edema, alopecia, bradycardia, vitamin B12 deficiency
SE of octreotide and lanreotide
Diarrhea, antibody formation, elevation of liver transaminase
Lipohypertrophy
SE of pegvisomant
Gonadorelin
Leuprolide
GnRH analog
Ganirelix
GnRH antagonist
Menotropin
LH and FSH
Gonadotropin Releasing Hormone Agonists MOA
GPCR – IP3 pulsatile administration ↑ FSH, LH
continuous administration down regulation of GnRH
receptors ↓ FSH, LH ↓ estrogen, testosterone
Hot flashes, depression, diminished libido, generalized pain, vaginal dryness, and breast atrophy
SE of GnRH agonist
Competitive antagonist at GnRH receptors ↓ IP3 ↓ FSH & LH
GnRH antagonist
Conivaptan antagonist of V1a and V2 receptors
Uses: Hypervolemic, euvolemic hyponatremia, SIADH, & heart failure
Tolvaptan more selective for V2 ↑ free water clearance ↓ urine osmolality ↑ serum sodium concentrations.
Use: Autosomal dominant polycystic kidney disease, SIADH, cirrhosis