HPA drugs Flashcards

1
Q

Pseudotumor cerebri, slipped capital femoral epiphysis, scoliosis, edema, hyperglycemia, asphyxiation in severely obese patients with Prader-Willi syndrome
Patients with turner syndrome  risk of otitis media
Pancreatitis, gynecomastia, and nevus growth
Peripheral edema, myalgia, and arthralgia

A

SE of GH

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2
Q

Recombinant Human IGF-1

A

given when IGF-1 issue with receptor of GH

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3
Q

Hypoglycemia
Intracranial hypertension, lipohypertrophy, elevation of liver enzymes

A

SE of recombinant human IGF-1

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4
Q

sermorelin
somatropin

A

GH

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5
Q

Octreotide, Lanreotide

A

Somatostatin analogs

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6
Q

Pegvisomant

A

Growth hormone receptor antagonist

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7
Q

Nausea, vomiting, abdominal cramps, flatulence, steatorrhea, biliary sludge, gall stones, hypertension, peripheral edema, alopecia, bradycardia, vitamin B12 deficiency

A

SE of octreotide and lanreotide

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8
Q

Diarrhea, antibody formation, elevation of liver transaminase
Lipohypertrophy

A

SE of pegvisomant

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9
Q

Gonadorelin
Leuprolide

A

GnRH analog

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10
Q

Ganirelix

A

GnRH antagonist

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11
Q

Menotropin

A

LH and FSH

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12
Q

Gonadotropin Releasing Hormone Agonists MOA

A

GPCR – IP3  pulsatile administration  ↑ FSH, LH
 continuous administration  down regulation of GnRH
receptors  ↓ FSH, LH  ↓ estrogen, testosterone

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13
Q

Hot flashes, depression, diminished libido, generalized pain, vaginal dryness, and breast atrophy

A

SE of GnRH agonist

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14
Q

Competitive antagonist at GnRH receptors  ↓ IP3  ↓ FSH & LH

A

GnRH antagonist

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15
Q

Conivaptan antagonist of V1a and V2 receptors
Uses: Hypervolemic, euvolemic hyponatremia, SIADH, & heart failure
Tolvaptan more selective for V2  ↑ free water clearance  ↓ urine osmolality  ↑ serum sodium concentrations.
Use: Autosomal dominant polycystic kidney disease, SIADH, cirrhosis

A
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16
Q

Demeclocycline & Lithium: act on the collecting tubule cell to diminish its responsiveness to ADH, thereby increasing water excretion.
Use: SIADH

A