drugs for male Flashcards
Development of penis, scrotum, prostate early life, later it increases growth of prostate, baldness, sebum. Male external structure development in fetus
DHT
Masculinization, hirsutism, acne, gynecomastia ( breast become larger), amenorrhea- loss of menstruation, clitoral enlargement, and deepening of the voice, alter serum lipids, aggression, psychotic episodes
Sodium retention and edema
Hepatic dysfunction, jaundice
Prostatic hyperplasia, urinary retention
SE of test.
Pregnancy (Masculinization of female fetus), infants, young children, cardiac disease
Carcinoma of the prostate & breast
CT of Test.
Hepatotoxicity, Jaundice, dyslipidemia, shrinkage of the testes & male infertility, gynecomastia, masculinization of woman, dyslipidemia, MI & stroke
SE of oxandrolone
recurrent mammary cancer in postmenopausal women
Hypogonadism or delayed puberty
Abuse- (use for )Physical performance in athletes
uses of oxandrolone
direct binding to and activation of sex hormone receptors, direct inhibition of enzymes involved in steroidogenesis, and direct binding to and occupation of steroid hormone carrier proteins and consequent displacement of steroid hormones from these proteins.
DANAZOL
antigonadotropin and antiestrogen activities)
Endometriosis: as an inhibitor of gonadal function
Fibrocystic breast disease
Heavy menstrual bleeding
Hereditary angioedema (of all causes) in men & women
use of danazol
Thromboembolism
Androgenic effects; hirsutism, oily skin, acne & menstrual irreg.
Decreased HDL, possible increase in LDL
Hepatotoxicity
SE of danazol
Abiraterone
17-alfa hydroxylase inhibitor
Rx. Prostate cancer
Finasteride, Dutasteride
5-alfa reductase inhibitors ↓ DHT ↓ prostate size in BPH
Tamsulosin
Competitive α1-blocker; Relax bladder, urethral, & prostate smooth muscle; ↓Urinary symptoms caused by BPH.
Androgen Receptor Antagonists:Flutamide, Bicalutamide, Cyproterone & Spironolactone
Non-steroidal, competitive antagonist at the androgen receptor
With GnRH analog (e.g., Leuprolide) to treat inoperable prostate cancer
Gynecomastia
Impotence
Hot flashes
Hepatitis
SE of androgen receptor antagonist
Phosphodiesterase-5 (PDE-5) inhibitors
Sildenafil, Tadalafil, Vardenafil: ↑cGMP smooth muscle relaxation in corpus cavernosum ↑ blood flow Penile erection
Headache
Flushing, hypotension
Dyspepsia
Blue vision, hearing loss
SE pf PDE-5 inhibitors
