HPA Flashcards
HPA
Hypothalamic pituitary adrenal axis
CRH
corticotrophic-releasing hormone
goes into the pituitary gland to release ACTH
Hypothalamus
acts as a sensor and mediator between other glands
Trophic hormones
Hormones that releases other hormones
Pituitary gland
Secretes hormones made by the hypothalamus and is more of an extension of neuron tissues
Anterior pituitary gland
The true endocrine gland as it releases its own hormones but still regulated by hypothalamic hormones
Posterior pituitary
Acts more of like an extension of the hypothalamus. Stores and releases hormones and also contains axons that originates from hypothalamic neurons
The effect of cortisol
Provides body with glucogenesis as a response to stress
Inhibits ACTH secretion as a feed back
Decreases anabolic pathway and increases catabolic pathway
Adrenal gland parts
Adrenal cortex and medulla
Adrenal cortex zones
Zona glomerulosa
Zona fasciculata
Zona reticularis
Adrenal medulla
Secretes catecholamines (amine hormones) like adrenaline, noradrenaline and dopamine
Hypercortisolism
Excess of cortisol
Cushing’s syndrome
Results in tumors in the adrenal gland or pituitary
Hypercortisolism
Significant lack of cortisol
Addison’s disease