How the liver processes drugs & toxins

Question 1

What is the Michaelis-Menten equation?

Answer 1

Question 2

What is the purpose of Phase I metabolism?

Answer 2

to expose or create a chemically reactive group on the drug to facilitate further metabolic processing in Phase II

Question 3

What is the purpose of Phase II metabolism?

Answer 3

deactivate the drug

make the drug water soluble

Question 4

How is a drug typically made water-soluble?

Answer 4

by replacing the drug’s pharmacophoric regions with a sugar or sulphate group

Question 5

What are cytochrome P450 enzymes?

Answer 5

the most significant family of Phase I enzymes

responsible for oxidative modification

Question 6

What is the MOA of UDP-glucuronosyl transferase?

Answer 6

conjugate a water soluble glucuronide to the drug/metabolite

Question 7

What is considered a toxic dose of paracetamol?

Answer 7

4g - 6g

Question 8

What is considered a lethal dose of paracetamol?

Answer 8

>12g in one go

Question 9

How is paracetamol normally metabolised?

Answer 9