How cancers behave Flashcards

1
Q

What do epithelial cells do

A

Line the inside and outside of the body resting on a basement membrane

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2
Q

Outside exposure epithelium

A

squamous epithelium

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3
Q

skin

A

keratinising with adnexal structures

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4
Q

Internal

A

Non-keratonising

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5
Q

What types of glandular epithelium are there

A

G cells, parental cells, chief cells ect

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6
Q

what is ciliated epithelium

A

speudostratified ciliated columnar

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7
Q

transitional epithelium

A

bladder

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8
Q

What does carcinoma mean

A

EPITHELIAL malignancy

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9
Q

The older you are the higher the risk is for an epithelial malignancy true/false

A

true

due to long term accumulation of environmental risk factors

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10
Q

Who rarely gets carcinomas

A

Children

children tend to get blood, brain and bone cancer

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11
Q

what are brain lesions in older patients

A

carcinoma metastasis unless proven otherwise

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12
Q

What is the disease progression of carcinomas

A

Local growth
spread via haematogenous and lymphatic routes
different patterns of spread for different tumours

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13
Q

metastasis from lung goes to

A

bone
brain
adrenal
liver

Breast cancers also commonly go here

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14
Q

Where do GI malignancies metastasise to

A

Liver

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15
Q

Where does prostate cancer metastasise to

A

anywhere

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16
Q

Smooth muscle cancer

A

leiomyoma/sarcoma

17
Q

skeletal muscle

A

Rhabdomyosarcoma / sarcoma

18
Q

Sarcoma spread

A

Mainly local invasion - get v big

little lymphatic spread

19
Q

what do sarcomas look like

A

spindle cell lesions - elongated and tapered shape to cells. Solid.

20
Q

What suggests lymphoma

A

large lymph nodes across areas that dont fit with anatomical drainage of an epithelial malignancy

may involve liver and spleen - organomegaly

21
Q

Melanoma

A

malignant tumour of melanocytes (melanin forming cell in skin)

22
Q

Brain tumours

A

Gliomas
v rare
lesions in the brain - metastatic unless proven otherwise
dont really spread anywhere else due to blood brain barrier

23
Q

types of lung cancer

A

small cell
large cell
squamous cell
adenocarcinoma

24
Q

How do differentiate between lung cancers

A

test for the molecular abnormality so you can treat that