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prosto lec > HOST IMMUNE RESPONSE > Flashcards

HOST IMMUNE RESPONSE Flashcards

1
Q

Always there with, or without any bacterial invasion, or without the presence of invading microorganism

A

INNATE IMMUNE SYSTEM

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2
Q

The periodontium protects itself in an innate way:

A
  1. Stratification of sulcular & junctional epithelium. Continue cycling of the cell of the sulcular epithelium.
  2. Flushing effect of gingival crevicular fluid-contains physiologic immune surveillance, which is the
    polymorphonuclear nuclear cell which are the neutrophils
  3. Resident macrophage of the tissue which is the larger than cell.
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3
Q

is a fluid that came from your ground substances, plasma the blood, and goes to the interfacial spaces

A

transudate

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4
Q

high protein content on the fluid: contains products of inflammation.

A

exudate

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5
Q

2 COMPONENTS OF BLOOD

A

● Serum

● Plasma

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6
Q

devoid of zymogen (no
zymogen) - No Clotting factor

A

Serum

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7
Q

white blood cell

A

Leukocytes

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7
Q

Factors that causes cascading effect for clotting (hemostasis) and immune response

A

Zymogen

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8
Q

has zymogen - with clotting factor

A

Plasma

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8
Q

(red blood cell) Biconcave of the blood

A

Erythrocyte

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8
Q

enucleated cells

A

Thrombocytes or platelets

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8
Q

Cellular elements (three basic components of blood)

A
  1. Erythrocyte (red blood cell)
  2. Thrombocytes or platelets
  3. Leukocytes
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9
Q

In circulation. Once it has
migrated to the tissue, it is now
called a macrophage

A

Monocyte

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9
Q

2 GROUPS OF LEUKOCYTES:

A
  1. Granulocytes
  2. Agranulocytes
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9
Q

depending on the tissue where
the monocyte has migrated to
the tissue:

A

○ In the periodontiumLangerhans cells

○ Brain- microglial cells

○ Liver- Kupffer cell

○ Lungs - dust cells

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10
Q
  1. Lymphocytes
    a. T lymphocytes (T cells)
A

i. Cytotoxic t cell

ii. Helper t cell

iii. Regulatory t cell

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10
Q

Most reactive with the presence of
antigen

A

IgM.

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10
Q

unknown

A

IgD. -

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10
Q

3 granular cells

A
  1. neutrophil (most dominant)
  2. eosinophil (2nd most dominant)
  3. basophil
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11
Q

Most Predominant Secretions

A

IgG.

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11
Q

b. B lymphocytes (B cells)

A
  1. IgG.
  2. IgM.
  3. IgA.
  4. IgD.
  5. IgE.
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12
Q

There are two cells

A
  1. Resident Macrophage
  2. Neutrophil
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12
Q

Found in the secretion of saliva,
GCF, tears

A

IgA.

13
Q

Allergies

A

IgE. -

14
Q

The microorganisms whether gram + or gram -, have antigen on its surface. ANTIGEN is on the surface of an microorganism

A

MICROBE - HOST INTERACTION

15
Q

(Membrane attack
complex). Creates and dissolves t

A

C5b67689

16
Q

Fragmentation that activated the basophil and mast cell to liberate or secrete heparin and histamine

A

C3a/C4a/C5a

17
Q

This walling off of the fibrinogen creates a semi-clotted fluid
that prevents the spread of the infection in the area.

A

WALLING OFF EFFECT

17
Q

at the same time, it causes opsonization - activates phagocytosis.

A

C4 a and C5 a

18
Q

2 Phagocytosis in periodontium

A
  1. Langerhans Cells
  2. Neutrophils
19
Q

resident macrophage (Tambay lng sa tissue)

A

Langerhans Cells

20
Q

There is also activation of resident cells (Epithelial cells and fibroblast).

A

Neutrophils

21
Q

What happens, the neutrophil would tumble down in the cellular wall and the vascular wall and
attached on the surface because the endothelial cell has receptors called

A

INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)

22
Q

the neutrophil would tumble down to the surface of the vascular wall and attached on that surface
called ROLLING ADHESION.

A

ROLLING ADHESION

23
Q

predominant cells are neutrophils during acute inflammation

A

Acute inflammation

24
Q

lymphocytes and monocytes or macrophages predominant cells

A

Chronic inflammation

25
Q

T-cell cytotoxic cell, helper t-cell, t
regulatory cell

A

cytotoxic cell, helper t-cell, t
regulatory cell

26
Q

cannot recognize the presence of antigen

A

Cytotoxic cell

27
Q

cannot recognize the presence of antigen

A

Helper t-cell

28
Q

presenting cells - the role of this
is to present antigen to t-cells

A

Antigen

29
Q

Three antigens presenting cells in
immune cells

A
  1. Macrophages
  2. B-cell
  3. Dendritic cells
30
Q

most potent | the bridge
between innate immunity and adaptive immunity

A

Dendritic cells

31
Q

transport into plasma cell in
order to create antibodies or immune gamma globulins.

A

B-cell

32
Q

When the dendritic cells present
antigens to t-cells, they attach
themselves to the presence of the
antigen of the microorganism.

A

Dendritic cells

33
Q

Two types of major histocompatibility complex:

A
  1. Major histocompatibility complex 1
  2. Major histocompatibility complex 2
34
Q
  • For the positive feedback mechanism of
    phagocytes
  • For macrophage and neutrophil
A

INTERLEUKIN 1

35
Q

for the positive feedback mechanism for cytotoxic (cd8) t cell and helper T cell (cd4)

A

INTERLEUKIN 2

36
Q

for maturation of lymphoblasts
(precursor cell of lymphocytes)

A

INTERLEUKIN 3

37
Q

called as B cell differentiation unit
(collectively) ; maturation of b cell to
become plasma cell; plasma cell create immunoglobulin cell M,A,G,E,D.
- M - Most reactivet in the presence of antigen
- G - most predominant secretions
- A - found in secretions (Example: saliva,
tears, gingival crevicular fluid)
- E - for allergies
- D - no certain function/ unknown

A

INTERLEUKIN 4, 5, 6

38
Q

Triggers pluripotential/multipotent
hematopoietic stem cell to mature into granulocyte and monocyte

A

GRANULOCYTE, MONOCYTE, COLONY STIMULATING FACTOR/UNIT

39
Q

When cytokine is liberated by epithelial cells or the resident cells it is called

A

CYTOKINE

40
Q

In helper T cells they are called blank because they are created by the lymphocytes.

A

LYMPHOKINES

41
Q

Adipocytes also create interleukins and they are called

A

ADIPOKINES

42
Q

ACUTE RESOLUTION OF INFLAMMATION

A
  • Inflammation must have an acute
    response to prevent or stop disease from progressing.
  • Once the microorganism is completely eliminated, resident cells would create anti inflammatory cytokines (lipoxins,
    resolvins, protectins)
43
Q

Functions of Lipoxins, Resolvins, Protectins

A
  1. Stops macrophage transmigration
  2. Stop recruitment of immune cells
  3. Activate lymphatic system and drainage of byproduct of inflammation

prosto lec (4 decks)

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