Hospital Aquired Infecttions Flashcards

1
Q

What is a HAI?

A

An infection that patients get while receiving treatment for medical or surgical conditions

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2
Q

Where can your pick up a HAI?

A

Different types of healthcare settings:
- acute care hospitals
- GP practises
- outpatient clinics
- hospices
- long term care facilities

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3
Q

What are the 2 main central line associated infections?

A

CLABSI —> central line associated blood stream infection
—> germs enter bloodstream through tube place in large vein

MRSA —> methicillin resistant staphylococcus aureus

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4
Q

How can you prevent HAI?

A

Proper education and training

Careful insertion, maintenance and prompt removal of catheters

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5
Q

what are risk factors for HAI?

A

Medical procedures

Antibiotic use

Patients characteristics

Behaviour of healthcare staff

Healthcare facility

Length of hospital stay

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6
Q

What are the 6 links in the chain of infection?

A
  1. Infectious agent or germ
  2. Reservoir
  3. Portal of exit
  4. Mode of transmission
  5. Portal of entry
  6. Susceptible host
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7
Q

What are the 3 types of reservoirs?

A

Human reservoir

Animal reservoir

Environmental reservoir

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8
Q

What is a human reservoir?

A

Person to person

—> relatively easy for eradication —> narrow down to last human case

E.g STDs, measles, mumps

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9
Q

What is an animal reservoir?

A

Pathogens in animals

—> human is the incidental host

E.g SARS - CoV -2

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10
Q

What is an environmental reservoir?

A

Plant, soil, water

E.g many fungal agents

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11
Q

What are examples of portals of exit?

A

Path by which pathogen leaves the reservoir/host

—> bodily fluids

—> coughs

—> sneezes

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12
Q

What are the two types of mode of transmission?

A

Direct

Indirect

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13
Q

What are the types of direct transmission?

A

Direct contact —> skin to skin, kissing, intecourse

Droplet spread —> spray, aerosols, coughing, talking

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14
Q

What are the types of indirect transmission?

A

Airborne —> suspended air particles —> dust or droplet nuclei

Vehicle-borne —> inanimate objects —> food, water, blood, famites

Vector-borne —> animate intermediates

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15
Q

What are the 2 types of vector-borne transmission?

A

Mechanical —> animal carries pathogen from 1 host to another but doesn’t get infected itself

Biological —> Pathogens reproduces w/in biological vector

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16
Q

What does a susceptible host depend on?

A

Genetic or constitutional factors

Specific immunity

Non-specific factors

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17
Q

What does specific immunity include?

A

Infection or vaccine

Trans placental —> mother to foetus

18
Q

What does non-specific immunity involved?

A

Skin, mucous membrane, coughing reflex …

Acquired —> malnutrition, alcoholism, disease, therapy (chemo)

19
Q

What are some control measures?

A

Control eliminate agent at source —> antibodies, treat infected individuals

Mode of transmission —> isolating, eliminate/decontaminate vehicle, ventilation

Portals of entry —> mosquito nets, mask/gloves

20
Q

What are the 5 moments of hand hygiene?

A
  1. Before touching a patient
  2. Before clean/aseptic procedures
  3. After body fluid exposure risk
  4. After touching a patient
  5. After touching patient surroundings
21
Q

What is sepsis?

A

Body’s extreme reaction to an infection

22
Q

What is shock?

A

An imbalance in supply and demand

23
Q

What is the sequence of septic shock?

A
  1. Blood pressure drops
  2. Tachycardia —> increased HR to increase BP
  3. Respiratory rate goes up
24
Q

In what way are antibiotics given for sepsis and why?

A

IV —> faster delivery + systemic effect

25
What happens in the altered target site of antibiotic resistance?
Acquisition of alternative gene or gene that encodes a target-modifying enzyme —> alters structural conformation of protein that antibiotic targets
26
What happens in decreased drug accumulation of antibiotic resistance?
Reduced penetration of antibiotic or increased efflux of antibiotic
27
What happens in the altered mechanism profile of antibiotic resistance?
Switch to other metabolic pathways Increased production of enzyme substrate can outcompete the antibiotic inhibitor
28
What happens in the inactivation of antibiotic of antibiotic resistance?
Enzymatic degradation or alteration rendering antibiotic ineffective
29
What does beta-lactam antibiotics contain?
Beta-lactam ring
30
How do beta-lactate antibiotics work?
Interfere w/ synthesis of peptidoglycan By mimicking components of the cell wall Enzymes in bacteria confuse B-lactate antibiotics for cell wall precursors Bind to it Deactivates it Halts cell wall production Cell wall loses structural integrity Cell lysis
31
What are Beta-lactamases?
Enzymes produced by bacteria to provide resistance to beta-lactate antibiotics
32
What are beta-lactamase inhibitors?
Medication used to inhibit activity of beta-lactamases —> allow beta-lactam antibiotics to work properly
33
What is co-amoxiclav?
Antibiotic consisting of both amoxicillin an clavulanic acid
34
What is clavulanic acid?
Beta-lactamase inhibitor —> prevents breakdown of amoxicillin
35
How can other germs become antibiotic resistant quickly?
Resistance genes are often found in plasmids —> bacteria can share their DNA
36
How are plasmids a source of antibiotic resistance genes?
Has extra chromosomal circular DNA that often carries multiple resistance genes
37
How can transposons be a source of antibiotic resistance genes?
They are molecular shuttles that integrate plasmids into chromosomal DNA
38
How can naked DNA be a source of antibiotic resistance?
DNA from dead bacteria released into the environment —> bacteria can incorporate it into their own DNA
39
How are bacteriophages a source of antibiotic resistance?
They are viruses that attack bacteria and carry DNA from germ to germ
40
What is transduction?
Resistance genes can be transferred from one gene to another via bacteriophages
41
What is conjugation?
Resistance genes can be transferred between germs when they connect via a pilus
42
What is transformation?
Extracellular resistance genes released form nearby live or dead germs can be picked up directly by another germ