Hormones and receptors Flashcards

1
Q
  1. Distinguish the structure of peptide, steroid and thyroid hormones.
A

tyrosine derivatives- dop, epi, NE
-hydrophilic
-free hormones (but also degraded quickly, -short t1/2
peptides- hypothalmic hormones
-hydrophilic
-free hormones (but also degraded quickly, short t1/2
proteins- insulinm GH
-hydrophilic
-free hormones (but also degraded quickly, -short t1/2
steroids- estrogen testosterone
-hydrophobic

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2
Q
  1. Contrast the structures and cellular locations of the peptide and the steroid/thyroid hormones types of receptors.
A

peptide- GCPR, JAK-STAT, EGF-TYROSINE
-transmembrane
Steroid- intracellular–>transported to nucleus–>SRE’s–>gene transcription

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3
Q
  1. Identify the mechanisms of signaling of peptide hormones.
A

GCPR
Gs
Gi
Gq

JAK-STAT- Tyrosine kinase receptors–>janice kinase signal transducers and activators of transcription

EGF-TYROSINE–> EGFR–>Tyrosine kinase dimerize–»

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4
Q
  1. Compare the mechanisms of action of steroid and thyroid hormones.
A

1

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5
Q
  1. Identify different forms of regulation of hormone synthesis and release.
A

pulsatile release

circadian regulation

feedback regulation

endproduct regulation

receptor down regulTION

spare receptors

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