Hormones and receptors Flashcards
- Distinguish the structure of peptide, steroid and thyroid hormones.
tyrosine derivatives- dop, epi, NE
-hydrophilic
-free hormones (but also degraded quickly, -short t1/2
peptides- hypothalmic hormones
-hydrophilic
-free hormones (but also degraded quickly, short t1/2
proteins- insulinm GH
-hydrophilic
-free hormones (but also degraded quickly, -short t1/2
steroids- estrogen testosterone
-hydrophobic
- Contrast the structures and cellular locations of the peptide and the steroid/thyroid hormones types of receptors.
peptide- GCPR, JAK-STAT, EGF-TYROSINE
-transmembrane
Steroid- intracellular–>transported to nucleus–>SRE’s–>gene transcription
- Identify the mechanisms of signaling of peptide hormones.
GCPR
Gs
Gi
Gq
JAK-STAT- Tyrosine kinase receptors–>janice kinase signal transducers and activators of transcription
EGF-TYROSINE–> EGFR–>Tyrosine kinase dimerize–»
- Compare the mechanisms of action of steroid and thyroid hormones.
1
- Identify different forms of regulation of hormone synthesis and release.
pulsatile release
circadian regulation
feedback regulation
endproduct regulation
receptor down regulTION
spare receptors