Hormones Flashcards
What are hormones?
chemical messengers in the blood, secreted by endocrine organs
hormones are tightly regulated - this means that
small imbalances can cause abnormalities
John Hunter: 1728 - 1793
when roosters are castrated the comb collapses - he put testes back into the body, and the comb became erect again
Arnold Berthold: 1849
- reproduced hunter’s experiment in a more ‘scientific’ way
- took a fully severed testicle and put it back into the body cavity
- rooster showed normal sexual behaviour and comb development
- thought: maybe testes release something into the blood
Thomas Addison: 1855
noticed how people who had atrophied adrenal glands also had poor appetites and low blood pressure, weakness, anemia, and bronzed skin
Dolanski: 1849
- asked: How do organs know that food had been ingested and to therefore release digestive juices?
Dolanski’s hypothesis
maybe the level of acidity increased after eating food - this increase would cause a message to be sent to the pancreas and the liver
Dolanski’s experiment
injected acid into the rectum of the dog - thought it would be absorbed into the blood stream
Dolanski’s results
no flow of digestive juices
Charles Brown - Sequard: 1889
- self injected with macerated dog testicles to try and feel young again and apparently it worked
Charles brown repeated his experiment with…
monkey gland extracts
Brown introduced
“hormone therapy”
Napolean Cybulski: 1895
- obtained adrenal gland extract (including adrenalin)
- injected it to people to increase their blood pressure
Serge Voronff
- human testicle extract would be better
- took the testes of executed criminals and proved that it helps older men feel youthful
Sir Arthur Conan Doyle mocked all of these guys and wrote the book
“the adventure of the creeping man”
John Romulus Brinkley capitalized whose idea?
Sequard’s idea
Brinkley grew a farm of …
horny goats
he carried out ____ procedures in which he implanted the goat testes into humans
over 1,700
In 1895 it was discovered that ____ _____ could be injected to raise blood pressure
adrenalin extract
Ernest Starling - 1902
had the same question as dolanski
Starling’s hypothesis
maybe the message is relesased by the duodenum
Starling’s experiment
- fed food to a dog
- removed a small piece of the duodenum
- macerated the duodenum
- injected it into another dog’s blood
Starling’s results
digestive juices were immediately released
The substance that is released by the duodenum after eating food is…
secretin
Pituitary gland is the
master endocrine gland
pituitary gland recieves input from the …
hypothalamus and other systems
pituitary gland secretes how much per day of hormones?
1 ug/day
where is the pituitary gland located?
in the brain below the hypothalamus
the pituitary gland is known as the
conductor of hormonal orchestra
prolactin
tells breasts to produce milk after giving birth
somatotripon
growth hormone
adrenocoritoctropic hormone (ACTH)
stimulates adrenals
follice stimulating hormone (FSH)
gonads
thyrotropin stimulating hormone
thyroid
excess amount of Somatrotripon
usually caused by a tumour
Daniel Redman experiment
injected human growth homrone into elderly men
Redman results
- increase in muscle and other lean tissue
- decrease in fatty tissue
- increase n skin thickness
- increase in the average denstiy of lower-back verebrate
Redman’s experiment acused
- increase in blood pressure
- plasma glucose increase
- carpal tunnel syndrome
- breast enlargment
Where there measurable improvements in muscle function or physical performance
NO
where was an improvement in muscle-fat distribution?
YES
do we have a hGH (human growth hormone)
nope.
what time of hormone is the hGH
protein hormone
Secretagogue is a
mixture of acids
how does the secretagogue work?
causes the body to secrete more hGH
analogy for secretagogue
taking a truckload of windows and doors and seeing if they’ll assemble and make themselves into a building
gigantism is due to the overproduction of..
growth hormone
Bovine somatotropin is also known as
bovine growth hormone (bgh)
which land is bgh secreted by?
pituitary
bgh can increase milk yield by …
20%
porcin somatotropin is..
the same thing but for pigs
Thyroid gland controls the
metabolism