Hormones Flashcards

1
Q
Abbreviations: 
CRH
DHEA
DIT
DOC
HCG
HPL
IGF
A
Corticotropin-releasing hormone
Dehydroepiandrosterone 
Diiodotyrosine 
11-Deoxycorticosterone 
Human chorionic gonadotropin 
Human placental lactogen 
insulin like growth factor
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2
Q
Abbreviations:
T3 
T4
TBG
TRH
TSH
A
Triiodothyronine
Thyroxine 
Thyroxin binding globulin 
Thyrotropin releasing hormone
Thyroid stimulating factor
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3
Q
Abbreviations: 
MIT
MSH
PIF
POMC
PTU
SRIF
A
Monoiodotyrosine 
Melanocyte-stimulating hormone
Prolactin inhibiting factor (Dopamine) 
Pro-opiomelanocotrin 
Propylthiouracil 
Somatotropin releasing-inhibiting factor
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4
Q

Peptide hormones released by the Hypothalamus?

A
TRH
CRH
GnRH
SRIF
PIF
GHRH
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5
Q

Peptide hormones released by the Anterior Pituitary Gland?

A
TSH
FSH
LH
GH
Prolactin
ACTH
MSH
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6
Q

Peptide hormones released by the Posterior Pituitary gland?

A

Oxytocin

ADH

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7
Q

What are all the STEROID Hormones?

A
Cortisol 
Aldosterone 
DHEA
Testosterone
Estradiol 
Progesterone 
Estriol 
1,25- Hihydroxycholecalciferol
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8
Q

Hormones released by the Thyroid?

A

Calcitonin (amine)
T3 (peptide)
T4 (peptide)

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9
Q

Hormones released by Adrenal Cortex + Medulla?

A

Cortex: Steroids Medulla:
Cortisol NE + Epi (amines)
Aldosterone
DHEA

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10
Q

Steroid hormones produced by Ovaries?

A

Estradiol

Progesterone

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11
Q

What does the Corpus luteum produce?

A

Estradiol + Progesterone

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12
Q

Hormones produced by Placenta?

A

HCG (peptide)
HPL (peptide)
Estriol (steroid)
Progesterone

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13
Q

Peptide hormones produced by Pancreas?

A

Insulin (BETA cells)

Glucagon (ALPHA cells)

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14
Q

What is the function of Somatostatin or SRIF?

A

inhibit secretion of GH

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15
Q

What ist the function of GnRH?

A

Stimulate secretion of LH + FSH

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16
Q

What is the hormonal function of Dopamine (PIF)?

A

Inhibit prolactin secretion

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17
Q

What is the function of CRH?

A

Stimulates ACTH secretion

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18
Q

Function of FSH?

A

Stimulate Sperm maturation in Sertoli cells of testes

Stimulate Follicular development and estrogen synthesis in ovaries

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19
Q

Function of LH?

A

Stimulate Testosterone synthesis in LYNDIG cells

Stimulate Ovulation, Corpus luteum formation, estrogen and Progesterone synthesis in Ovaries

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20
Q

Function of ACTH?

A

Stimulates synthesis and secretion of Adrenal cortical hormones (Cortisol, androgens)

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21
Q

Function of Oxytocin?

A

Stimulates milk ejection from breasts and uterine contractions

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22
Q

Function of L-Thyroxine (T4)?

A
Stimulate skeletal growth 
oxygen consumption 
Heat production 
Protein + fat + carb utilization 
Perinatal maturation of CNS
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23
Q

Function of Calcitonin?

A

Decrease Ca++ in serum

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24
Q

Function of PTH?

A

Increase Serum Ca++

25
Q

Function of Cortisol?

A

Stimulate Gluconeogenesis
Inhibits inflammatory response
Suppresses immune system
Enhances vascular response to Catecholamines

26
Q

Function of DHEA/ Testosterone?

A

Stimulate Spermatogenesis

Stimulate male 2nd sex characteristics

27
Q

Function of Estradiol/ Estriol?

A

Stimulate growth/ development of female reproductive system
Stimulate Follicular phase of menstrual cycle
Development of Breasts
Prolactin secretion
Maintains Pregnancy

28
Q

HCG function?

A

Stimulates Estrogen and progesterone synthesis in Corpus luteum of early Pregnancy

29
Q

Function of 1,25 Dihydroxycholecalciferol?

A

Increase intestinal Absorption of Ca++

Bone mineralization

30
Q

Which hormones use Adenylyl cyclase mechanism of action (cAMP)?

A
ACTH
LH 
FSH 
TSH 
ADH
HCG
MSH
CRH
Calcitronin
PTH
Glucagon
Beta1 + beta 2 receptors
31
Q

Which hormones use Phospholipase C mechanism of action (IP3 + Ca++)?

A
GnRH
TRH
GHRH
Angiotensin II
ADH (V1 receptor)
Oxytocin
alpha receptors
32
Q

Steroid hormones?

A
Glucocorticoids
Estrogen 
Progesterone
Testosterone
Aldosterone
1,25-Dihydroxycholecalciferol 
Thyroid hormones
33
Q

Hormones with Tyrosine Kinase mechanism of action?

A

Insulin

IGF-1

34
Q

Hormones with Guanylate cyclase mechanism of action (cGMP)?

A

ANP
EDRF (endothelial derived relaxing factor)
NO

35
Q

What effect does Prolactin have on Hypothalamus?

A

Stimulates dopamine

Inhibits GnRH

36
Q

Which hormones act via cAMP?

A
ACTH
LH/ FSH
TSH
ADH (v2)
HCG
MSH
CRH
Calcitonin
PTH
Glucagon
Beta 1+2 receptors
37
Q

What hormones act via IP3/ Ca++?

A
GnRH
TRH
GHRH
Angiotensin II
ADH (v1)
Oxytocin
alpha 1 receptor
38
Q

Which hormones act via Tyrosine kinase?

A

Insulin

IGF-1

39
Q

Which hormones act via cGMP?

A

ANP
EDRF
NO

40
Q

What are the factors that stimulate Insulin secretion?

A
Increased Glucose
Increased AA
Increased FA or Ketoacid
Glucagon
Cortisol
GIP
Potassium 
Acetylcholine (Vagal stimulation)
Sulfonylureas (Tolbutamide or glyburide)
Obesity
41
Q

Factors that inhibit Insulin secretion?

A
Decreased Glucose
Fasting
Exercise
Somatostatin
alpha agonists
Diazoxide
42
Q

What are the actions of Insulin?

A
Increase Glucose uptake
Increase glycogen formation
Decrease Glycogenolysis
Decrease Gluconeogenesis
Increase protein synthesis
Increase Fat deposition 
Decrease lipolysis 
Increase K+ uptake
43
Q

Factors that stimulate Glucagon secretion?

A
Fasting/ Exercise
Decreased Glucose
Increased AA
CCK
Beta agonists
Acetylcholine
44
Q

Factors that inhibit Glucagon secretion?

A

Insulin
Somatostatin
Increased FA or Ketoacids

45
Q

What are the actions of Glucagon?

A

Increase Glycogenolysis
Increase Gluconeogenesis
Increase Lipolysis
Increase Ketoacid formation

46
Q

Which hormone secretion is increased by emotional input and sensory input from mother holding her child or anticipation of breast feeding?

A

Oxytocin

**Prolactin only secreted with SUCKLING not emotional triggers

47
Q

Insulin induced hypoglycemia will INCREASE the secretion of what hormones?

A
GH
ACTH
Cortisol
PRL 
Glucagon
Catecholamines
ADH
48
Q

Arginine infusion will increase secretion of?

A

GH

49
Q

Sleep study will show increase release of what hormones?

A

GH
PRL
ACTH
Cortisol

50
Q

L-dopa will increase the release of?

A

GH

51
Q

Increased plasma cortisol and adrenal androgens, increased skin pigmentation caused by?

A

Excess ACTH–> causes Adrenal Hyperplasia

52
Q

Increased Salt retention (HTN), insulin resistance, increased fat deposits, decreased skin collagen, proximal myopathy caused by?

A

Excess CORTISOL–> Cushing syndrome

53
Q

Clinical manifestations of excess cortisol are?

A
HTN
Hyperglycemia (DB Mellitus)
Central obesity (buffalo hump)
Easily bruised (PURPLE STRAIE)
Proximal weakness
54
Q

Hair growth, decreased LH/FSH, increased sebum, and decreased Libido is caused by?

A

Excess Adrenal Androgen

55
Q

What are the actions of Glucocorticoids?

A
Increases Gluconeogenesis
Increase Proteolysis
Increases Lipolysis
Decrease Glucose Utilization== Increase Insulin
Decrease Insulin sensitivity
Inhibit Inflammatory response
Increase alpha receptors on Vasculature
Inhibit Bone Formation
Increase GFR
Decrease REM sleep
56
Q

Actions of Mineralocorticoids?

A

Increase Na reabsorption
Increases K secretion
Increase H secretion

57
Q

Actions of Adrenal androgens in Females?

A

Stimulate pubic/ axillary hair growth
Stimulate Libido

males–> same as testosterone

58
Q

What are the actions of Progesterone?

A

Maintenance of Uterus
Development of breasts
inhibit FSH + LH secreted
Maintain pregnancy