Homologous Recombination Flashcards
Homologous recombination is the exhange of genetic material between two _
Strands of DNA conttaining long stretches of similar base sequences
In meiosis, recombination plays a critical role in _
The repair of double stranded nicks in DNA
How does recombination increase genetic diversity during meisosis?
By enabling the shuffling of genetic material during chromosomal crossover
In bacter, recombination is a major mechanism of _
DNA repair
In bacteria, recombination facilitates incorporation of _
DNA obtained by horizontal gene transfer
In viruses, recombination helps to shape _
Evolution
When are introduced foreign DNA sequences recognised as homolgous by cells?
When sequences upstream and downstream of the target gene location ar eidentical to those of the native DNA
How are knock out mice produced?
Genes in embryonic stem cells are rendered inactive. Homologous foreign DNA is introduced and swapped in
What kind of models has recombinatory techniques resulted in?
Mouse models of human disorder such as cancer, diabetes etc
