Hodgkins lymphoma

Question 1

Neoplastic cells in Hodgkin’s lymphoma are _

Answer 1

clonal germinal centre/post GC B-lymphocyte defined by presence of Reed-Sternberg cells

Question 2

bi modal age distribution

Answer 2

15&34 AND >60

Question 3

most common subtype

Answer 3

Nodular Sclerosing

Question 4

the nucleoli in R-S cells are _

Answer 4

Eosinophilic

Question 5

symptoms of Hodgkin’s Lymphoma
B symptoms

Answer 5

1) fever of 38degrees lasting over a month
2) drenching night sweat
3) weight loss >10% of baseline body weight within 6 months

Question 6

clinical features of HL

Answer 6

1) painless lymph node enlargement
2) b symptoms
3) pruritus
4) intrathoracic mass in 67% of px
5) Mediastinal adenopathy
6) Immunologic dysfunction
7) anaemia, pallor, fatigue

Question 7

what cells distinguish Nodular Sclerosing HL

Answer 7

Lacunar cells

Question 8

what HL type has a strong association with prior exposure to EBV infection

Answer 8

Mixed cellularity