Hodgkin's Lymphoma

Question 1

Hodgkin’s Lymphoma

Answer 1

Reed-Sternberg cells; CD15/30 (+)
-2 mirror image nuclei (“owl eyes”), each with an eosinophilic nucleolus, surrounded by a clear halo; of B-cell origin.

The RS cells secrete cytokines, leading to fever, weight loss, night sweats and itching.

Question 2

Nodular Sclerosis HL

Answer 2

Fibrous thickening of anterior mediastinal and either cervical or supraclavicular lymph nodes.

Lacunar type RS cells seen: RS cell in big spaces.

Excellent prognosis

Question 3

Lymphocyte-rich HL

Answer 3

Lots of lymphocytic and histiocytic (“popcorn”) cells are present. These cells are CD19/20 (+), but CD 15/30 (-)

Good prognosis

Question 4

Lymphocyte-depleted HL

Answer 4

Worst prognosis

Question 5

Mixed-cellularity HL

Answer 5

Abundant eosinophils due to IL-5. Associated with Epstein Barr Virus