Acute Leukemia Flashcards

1
Q

Acute Lymphoblastic Leukemia (ALL)

A

Newborn - 14 years old

TdT(+)

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2
Q

B-ALL

A

t(12;21): good prognosis

CD10, CD19, CD20

Commonly metastasize to testicles and CNS

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3
Q

T-ALL

A

CD10(-), CD2-8(+)

Can present as thymic mass

Tend to metastasize to skin

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4
Q

Acute Myeloblastic Leukemia (AML)

A

MPO(+)

APL, AMoL (Acute Monocytic Leukemia), Acute Megakaryoblastic Leukemia

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5
Q

Acute Promyelocytic Leukemia (APL)

A

DIC, Auer rods, t(15,17)

RAR is disrupted –> high doses of ATRA (all-trans retinoic acid) may induce remission –> differentiation into neutrophils –> apoptosis

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6
Q

Acute Megakaryoblastic Leukemia

A

Increased incidence in Down Syndrome (<3 yrs)

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