Hodgkin Lymphoma (HL)

Question 0

What do the Reed-Sternberg cells make? What does this cause?

Answer 0

Secrete cytokines.

1. B symptoms - fever, chills, weight loss
2. Attract reactive lymphocytes, plasma cells, macrophages, eosinophils
3. May lead to fibrosis

Question 1

What is Hodgkin’s lymphoma? What would you see on histology? What markers are positive for it?

Answer 1

Neoplastic proliferation of Reed-Sternberg cells which are B cells with multi-lobed nuclei and prominent nucleoli “owl eyed”. Positive for CD15 and CD30.

Question 2

What are the subtypes of Hodgkin’s lymphoma?

Answer 2

Nodular sclerosis
Lymphocyte-rich - best prognosis
Mixed cellularity - abundant eosinophils
Lymphocyte depleted - most aggressive, seen in elders or HIV + pts

Question 3

A 27 yo pt comes to your obgyn clinic for annual checkup. Physical exam shows an enlarging cervical lymph node. What do you think she has? What would biopsy show?

Answer 3

She has nodular sclerosis type of Hodgkin’s lymphoma which is the most common type. Lymph node is divided by bands of sclerosis. Reed-Sternberg cells are present in lake-like spaces.