Hodgkin Lymphoma

Question 1

What is Hodgkin Lymphoma?

Answer 1

Neoplastic proliferation of Reed-Sternberg cells which are large B cells with multilobed nuclei and prominent nucleoli (owl-eyed nuclei) CD15 and 30+;

Question 2

What are Reed-Sternberg cells’ actions?

Answer 2

Occasionally result in B symptoms (fever, chills, weight loss, night sweats), attract reactive lymphocytes, plasma cells, macros, eosinophils, can lead to fibrosis

Question 3

What makes up HL tumor? What subtypes are there?

Answer 3

Primarily reactive inflammatory cells; Nodular sclerosis, lymphocyte-rich (best prog), mixed cellularity, lymphocyte depleted (worst prog)

Question 4

What is the most common type of HL? Classic presentation? Histo findings?

Answer 4

Nodular sclerosis; Enlarging cervical or mediastinal lymph node in a young adult, usually female; Lymph node divided by bands of sclerosis with RS cells in lake-like spaces (Lacunar cells)

Question 5

What cell type in mixed cellularity HL associated with?

Answer 5

Eosinophils because RS produce IL-5

Question 6

What population is lymphocyte-depleted HL found?

Answer 6

Elderly and HIV-positive