HLA types and Hypersensitivity types

Question 1

HLA A3

Answer 1

MHC I-binds CD8

Hemochromatosis

Question 2

HLA B27

Answer 2

MHC I-binds CD8
PAIR (seronegative arthropathies)
Psoriatic arthritis
Ankylosing Spondylitis
arthritis of Inflammatory bowel disease
Reactive arthritis/Reiters

Question 3

HLA DQ2/DQ8

Answer 3

MHC II-binds CD4

Celiac disease

Question 4

HLA DR2

Answer 4

MHC II-binds CD4

Multiple sclerosis, hay fever, SLE, Goodpasture syndrome

Question 5

HLA DR3

Answer 5

MHC II-binds CD4

Diabetes mellitus type 1, SLE, Graves

Question 6

HLA DR4

Answer 6

MHC II-binds CD4

Rheumatoid arthritis, DM type 1

Question 7

HLA DR5

Answer 7

MHC II-binds CD4
pernicious anemia–>Vit B12 def
Hashimoto thyroiditis

Question 8

Type I Hypersensitivity

Answer 8

pre-formed Ig on sensitized mast cell binds allergen–>anaphylaxis–>histamine–>swelling
rapid reaction
-Anaphylaxis from bees, etc, Allergies/atopic: hay fever, exczema

Question 9

Type II Hypersensitivity

Answer 9

Antibody dependent reaction: (IgM, IgG)
Usually more localized to site of antibody
1.Cytotoxic: antibodies directly bind and cause death by opsonization, complement, or ADCC by NK cells
    -autoimmune hemolytic anemia
    -Rh factor-->erythroblastosis fetalis
    -pernicious anemia
    -rheumatic fever
    -Goodpasture
    -bullous pemphigoid
2.Altered function:
   -myasthenia gravis
   -Graves disease

Question 10

Type III Hypersensitivity

Answer 10

Immune COMPLEX! IgG-antibody complexes activate complement and cause neutrophil release of lysosomal enzymes
more systemic, often vasculitis
-serum sickness
-arthus reaction-local reaction to intradermal injection of protein
-SLE
-Polyarteritis nodosa
-Poststrep glomerulonephritis

Question 11

Type IV Hypersensitivity

Answer 11

Delayed (T-cell-mediated) response, NO antibodies, sensitized T cells encounter antigen-release lymphokines to draw macrophages

- Multiple Sclerosis
- Guillain-Barre after campylobacter
- Graft vs. host
- PPD
- Contact dermatitis (poison ivy)
- Hashimoto thyroiditis
- Celiac
- Rheumatoid arthritis
- Type 1 DM