CD Markers Flashcards

1
Q

CD2

A

T cells, thymocytes, NK cells

Adhesion

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2
Q

CD3

A

T cells, thymocytes

Signal transduction by TCR

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3
Q

CD4

A

TH cells, thymocytes, monocytes, and macrophages
Co-receptor for TCR-MHC-II
Receptor for HIV

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4
Q

CD8

A

CTLs, some thymocytes

Coreceptor for MHC I

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5
Q

CD14 (LPS receptor)

A

Monocytes, Macrophages, Granulocytes

Binds LPS

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6
Q

CD 16 (Fc receptor-bind antibodies attached to infected body cells)

A
NK cells, macrophages, neutrophils
Opsononization ADCC (Antibody-dependent cell-mediated toxicity) -->NK
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7
Q

CD18

A

Leukocytes-like neutrophils, Cell adhesion molecule for attaching to endothelium, (absent in Leukocyte Adhesion Deficiency)

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8
Q

CD19

A

B cells

Coreceptor w/ CD 21 for B cell activation

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9
Q

CD20

A

Most or all B cells

B cell activation

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10
Q

CD21 (CR2, C3d receptor)

A

Mature B cells
Receptor for complement fragment C3d, forms coreceptor CD19,
Receptor for Epstein-Barr Virus

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11
Q

CD25

A

Activated TH cells and Treg

Alpha chain of Il-2 receptor

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12
Q

CD28

A

T cells

T cell receptor for costimulatory molecule B7

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13
Q

CD34

A

Precursors of hematopoeitic cells, endotheliall cells in HEV

Cell-cell adhesion, binds L-selectin

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14
Q

CD40

A

Antigen Presenting Cells: B cells, macrophages, dendritic cells, endothelial cells
Binds CD40L, T cell dependent B cell, macrophage, dendritic cell and endothelial cell activation

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15
Q

CD56

A

NK cells

Unknown Function

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16
Q

CD152(CTLA-4)

A

Activated T cells

Negative regulation=competes with B7 for binding

17
Q

B7

A

Antigen Presenting cell receptor for CD 28

Must accompany MHC II/TCR and CD40/CD40L interactions

18
Q

MHC 1

A

On all body cells, binds to CD8 receptor on cytotoxic T cells

19
Q

MHC 2

A

On Antigen presenting cells, binds CD4 receptor on T helper cells

20
Q

CD15

A

Cell surface marker on neutrophils

On ReedSternberg cells- marker for Hodgkin lymphoma