HLA subtypes and disease Flashcards
1
Q
HLA A3
A
Hemachromatosis
2
Q
HLA B27
A
PAIR:
Psoriasis
Ankylosing Spondylitis
Inflammatory Bowel Disease
Reiter’s Syndrome
3
Q
HLA DQ2/DQ8
A
Celiac disease
4
Q
HLA DR2
A
MS, hay fever, SLE, Goodpasture’s
5
Q
HLA DR3
A
DM type I, Grave’s
6
Q
HLA DR4
A
RA, DM type I
7
Q
HLA DR5
A
Pernicious anemia –> B12 deficiency
Hashimoto’s
8
Q
What subtypes make MHC class I?
A
HLA A, B, C
9
Q
What subtypes make MHC class II?
A
HLA-DR, DP, DQ
10
Q
Where is MHC Class I found? What does it bind?
A
All nucleated cells (so not RBCs).
Binds TCR and CD8 (CD8 = cytotoxic T cells)
11
Q
Where is MHC Class II found? What does it bind?
A
APC
Binds TCR and CD4 (helper T cells).
