HLA and disease Flashcards
1
Q
HLA B27
A
Ankylosing spondylitis - 95% Psoriatic arthritis - 50% IBD-associated spondyloarthropathy - 50% Acute anterior uveitis - 50% Reactive arthritis - 10-70% Whipple's disease
Better prognosis in HIV
2
Q
HLA B51
A
Behcet’s disease
3
Q
HLA DR2
A
SLE Goodpasture's MS PBC AIH
Protective in DM
4
Q
HLA DR3
A
MG (and B8) Hashimoto's PSC Grave's T1DM SLE
5
Q
HLA DR4
A
RA
Pemphigoid
IgA nephropathy
T1DM
6
Q
HLA DQB1
A
Narcolepsy - >90%
7
Q
Coeliac
A
HLA DQ2, DQ8
8
Q
T1DM
A
HLA DR3, DR4
DR2 protective
9
Q
Carbamazepine
A
SJS: HLA B*1502
DRESS: HLA A*31:01
10
Q
Flucloxacillin
A
Liver failure: HLA B*5701
11
Q
Abacavir
A
Hypersensitivity: HLA B*5701
12
Q
HIV
A
Good
HLA B13, B27, B57
Bad
HLA A23, B37, B49
