HLA

Question 1

MHC

Answer 1

= Major Histocompatibility Complex

Question 2

HLA

Answer 2

= Human Leukocyte Antigen

Human equivalent of MHC
Chromosome 6p
Divided into Class I/II/III

Question 3

HLA Class I

Answer 3

Loci HLA-A, B, C

Expressed by all cells except RBCs and some neuronal cells

Present peptide to CD8 T cells - peptide derived from INTRACELLULAR infections

Consist of single 3-domain chain and beta-2-microglobulin

Question 4

HLA Class II

Answer 4

Loci HLA-DR, DP, DQ (&DM, DO)

Expressed only by specialised APCs - unregulated by inflammatory stimuli on other cells

Present peptide CD4 T cells - peptide derived form ingested EXTRACELLULAR Ag

Consist of two 2-domain chains, alpha and beta