HLA Flashcards
1
Q
Class 1 HLA
A
- A, B, C
- All nucleated cells
- Density varies from tissue to tissue
2
Q
Class 2 HLA
A
- DR, DQ, DP
- APCs
- B lymphocytes
- Activated T lymphocytes
3
Q
Most common caucasian HLA allele
A
HLA-A2
4
Q
Normal role of HLA molecules
A
Present pathogen derived peptides to the immune system
5
Q
Mismatched HLA molecules
A
Become the target of host immune response in transplant setting (rejection)
6
Q
Evidence that allograft rejection is immunologically mediated
A
- Latent Period
- Memory (2nd Set Rejection)
- Specificity
- Passive Transfer by lymphocytes
- Production of Antibodies
7
Q
Hyperacute rejection
A
- Preformed cytotoxic antibodies to donor antigens (or due to mismatched HLA)
- Complement activation, endothelial damage, inflammation, thrombosis
8
Q
Acute rejection
A
Development of allogenic reaction to donor antigens
9
Q
Chronic rejection
A
Multiple immune and non immune related factors (reversible
10
Q
Immunopathological reaction
A
Recurrence of original disease
11
Q
Recipient O
A
Donor O
12
Q
Recipient B
A
Donor B or O
13
Q
Recipient A
A
Donor A or O
14
Q
Recipient AB
A
A, B, AB, or O
15
Q
Mechanism of renal allograft chronic rejection
A
- Chronic endothelial damage and endothelial proliferation
- Ongoing cellular and vascular rejection
- Immune complex deposition
- Recurrence of original disease
